| Maspin BCSG1及c-erbB-2表达与乳腺癌预后的关系 |
| |
| 引用本文： | 刘巍,张祥宏,张志刚,王小玲,王俊灵,严霞. Maspin BCSG1及c-erbB-2表达与乳腺癌预后的关系[J]. 中国肿瘤临床, 2005, 32(8): 431-434 |
| |
| 作者姓名： | 刘巍 张祥宏 张志刚 王小玲 王俊灵 严霞 |
| |
| 作者单位： | 1. 河北医科大学基础研究所实验病理室,石家庄市,050017
2. 河北医科大学第四医院病理科 |
| |
| 摘 要： | 目的:探讨Maspin、BCSG1、c-erbB-2蛋白在乳腺癌中的表达及其与预后的关系.方法:选取临床病理资料完整并随访5年以上的137例乳腺癌病例,采用SP免疫组织化学技术检测乳腺癌组织中的Maspin、BCSG1、c-erbB-2蛋白的表达情况,结合临床及病理形态学资料用COX模型分析Maspin、BCSG1、c-erbB-2表达对预后的影响.结果:Maspin、BCSG1、c-erbB-2蛋白在乳腺癌组织中的阳性表达率分别为48.9%,67.2%,27.7%三者与生存时间显著相关(P＜0.01).结论:Maspin、BCSG1、c-erbB-2蛋白在乳腺癌中的表达与患者的生存期密切相关,可作为预测乳腺癌预后的参考指标.
|
| 关 键 词： | 乳腺癌 Maspin BCSG1 c-erbB-2 免疫组化 预后 |
| 文章编号： | 1000-8179(2005)08-0431-04 |
The Relationship between the Maspin, BCSG1 and c-erbB-2 Expression and the Prognosis of Breast Cancer |
| |
| Liu Wei Zhang Xianghong Zhang Zhigang et al Laboratory of Experimental Pathology,Hebei Medical University,Shijiazhuang. The Relationship between the Maspin, BCSG1 and c-erbB-2 Expression and the Prognosis of Breast Cancer[J]. Chinese Journal of Clinical Oncology, 2005, 32(8): 431-434 |
| |
| Authors: | Liu Wei Zhang Xianghong Zhang Zhigang et al Laboratory of Experimental Pathology Hebei Medical University Shijiazhuang |
| |
| Abstract: | Objective: To assess the relationship between the Maspin, BCSG1 and c-erbB-2 expression and the prognosis in breast cancer. Methods: The expression of ER, PR, Maspin, BCSG1, c-erbB-2 were determined with the SP immunohisto-chemical method in 137 cases with invasive breast cancer followed up over 5 years. Cox model was used to analyze the effect of Maspin, BCSG1 and c-erbB-2 expression and the clinopathological manifestations and prognosis in breast cancer. Results: The expression rate of Maspin, BCSG1 and c-erbB-2 was 48.9%, 67.2% and 27.7%, respectively, which were in relation with the survivals (P<0.01). Conclusion: The expression of BCSG1, c-erbB-2 and Maspin is closely related to the survival rate and can be used as the predictor of prognosis. |
| |
| Keywords: | Breast cancer Maspin BCSG1 c-erbB-2 Immunohistochemistry Prognosis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
