A note on the action of glutamine on cortical spreading depression |
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| Authors: | Pé ricles de Andrade Maranhã o-Filho,Aristides Azevedo Pacheco Leã o |
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| Affiliation: | Neurology Service, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Brazil. |
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| Abstract: | Application of a solution of 1-glutamine, 75 mM, to the pia-arachnoid surface of the dorsolateral neocortex of rabbits under dial-urethane anaesthesia was found to reversibly render the tissue insusceptible to spreading depression. It is suggested that this amide may play a part in the opposition normally offered by the tissue to undergo spreading depression. Some evidence is adduced which seems to support this suggestion. |
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| Keywords: | Glutamine migraine spreading depression |
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