| 丙型肝炎病毒侵染机制的相关研究进展 |
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| 引用本文： | 杨文祥,熊威,杨洁,樊柏林. 丙型肝炎病毒侵染机制的相关研究进展[J]. 世界华人消化杂志, 2011, 0(20): 2133-2140 |
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| 作者姓名： | 杨文祥 熊威 杨洁 樊柏林 |
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| 作者单位： | 湖北省疾病预防控制中心;武汉大学生命科学学院病毒学国家重点实验室; |
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| 摘 要： | 丙型肝炎在全世界约有1.7亿的感染人群,将近80％的患者会发展成慢性肝炎,最终导致肝硬化和肝癌.由于缺乏高效的细胞培养传代模型,使得丙型肝炎病毒(HCV)的生命周期的研究一直处于瓶颈,同时病毒自身高频突变,使得目前没有有效的疫苗药物进行预防和治疗.2005年Takaji Wakita,Charles M.Rice,Fr...
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| 关 键 词： | 丙型肝炎病毒 浸染机制 基因组多样性 研究模型 病毒生活周期 |
Mechanism of hepatitis C virus infection |
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| Wen-Xiang Yang,Bo-Lin Fan,Hubei Provincial Center for Disease Control , Prevention,Wuhan ,Hubei Province,China Wei Xiong,Jie Yang,State Key Laboratory of Virology,College of Life Sciences,Wuhan University,China. Mechanism of hepatitis C virus infection[J]. World Chinese Journal of Digestology, 2011, 0(20): 2133-2140 |
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| Authors: | Wen-Xiang Yang Bo-Lin Fan Hubei Provincial Center for Disease Control Prevention Wuhan Hubei Province China Wei Xiong Jie Yang State Key Laboratory of Virology College of Life Sciences Wuhan University China |
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| Affiliation: | Wen-Xiang Yang,Bo-Lin Fan,Hubei Provincial Center for Disease Control and Prevention,Wuhan 430079,Hubei Province,China Wei Xiong,Jie Yang,State Key Laboratory of Virology,College of Life Sciences,Wuhan University,China |
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| Abstract: | About 170 million persons are infected with hepatitis C virus (HCV) around the world, and nearly 80% of infected patients develop chronic liver disease that may eventually lead to liver cirrhosis or hepatocellular carcinoma. The mechanisms underlying the life cycle of HCV in the host are still largely unknown and the efforts made by researchers have been hampered by the absence of a robust system reproducing HCV infection. Moreover, there are no effective vaccines or drugs available to defend or exclude vir... |
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| Keywords: | Hepatitis C virus Infection mechanism Genome diversity Research model Virus life cycle |
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