| 中药清肠栓对溃疡性结肠炎大鼠结肠黏膜紧密连接蛋白ZO-1、occludin的影响 |
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| 引用本文： | 卢璐,谢建群,郭春荣.中药清肠栓对溃疡性结肠炎大鼠结肠黏膜紧密连接蛋白ZO-1、occludin的影响[J].世界华人消化杂志,2011(22):2322-2327. |
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| 作者姓名： | 卢璐 谢建群 郭春荣 |
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| 作者单位： | 上海中医药大学附属龙华医院;上海中医药大学; |
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| 基金项目： | 国家自然基金资助项目,No.30772801~~ |
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| 摘 要： | 目的:探讨复方中药清肠栓对三硝基苯磺酸(TNBS)诱导的UC大鼠结肠黏膜上皮紧密连接相关蛋白-l(ZO-1)、闭锁蛋白(occludin)的修复作用.方法:清洁级♂SD大鼠36只,随机分为正常组、模型组、SASP组、清肠栓高、中、低剂量组,每组6只.选用TNBS诱导的UC大鼠模型.采用免疫荧光的方法观察各组大鼠结肠黏膜...
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| 关 键 词： | 关键词:清肠栓 溃疡性结肠炎 紧密连接相关蛋白-1 闭锁蛋白 |
Qingchang Suppository upregulates the expression of tight junction proteins ZO-1 and occludin in experimental ulcerative colitis in rats |
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| Lu Lu,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai ,China Jian-Qun Xie,Chun-Rong Guo,Shanghai University of Traditional Chinese Medicine,Shanghai ,China.Qingchang Suppository upregulates the expression of tight junction proteins ZO-1 and occludin in experimental ulcerative colitis in rats[J].World Chinese Journal of Digestology,2011(22):2322-2327. |
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| Authors: | Lu Lu Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai China Jian-Qun Xie Chun-Rong Guo Shanghai University of Traditional Chinese Medicine Shanghai China |
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| Institution: | Lu Lu,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China Jian-Qun Xie,Chun-Rong Guo,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China |
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| Abstract: | AIM:To observe the effect of Qingchang Suppository(QS) on the expression of tight junction proteins zonula occluden-1(ZO-1) and occludin in the colon of rats with trinitrobenzenesulfonic acid(TNBS)-induced ulcerative colitis(UC).METHODS:Thirty-six SD rats were randomly and equally divided into six groups:normal control group,model group,SASP group,high-,medium-and low-dose QS groups.UC was induced in rats with TNBS.The expression of tight junction proteins ZO-1 and occludin in the colon was examined by immu... |
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| Keywords: | Qingchang Suppository Ulcerative colitis Zonula occluden-1 Occludin |
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