Antimotion effect of nooglutyl and its neuronal mechanism |
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Authors: | V V Yasnetsov V A Pravdivtsev V M Popov T A Voronina N M Kiseleva S B Kozlov |
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Institution: | (1) Industrial Research Center Gidrobios, Ministry of Health of Russia, Moscow |
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Abstract: | Experiments on rats demonstrate that nooglutyl exhibits pronounced vestibular-protective properties and by its antimotion
activity does not rank below classic vestibular protectors, such as scopolamine and diprazine. Electrophysiological experiments
on cats show that nooglutyl alters spontaneous activity in 80% of cortical neurons (somatosensory zone I and area 5 of the
parietal association cortex) and considerably weakens effects caused by motion sickness: activation of single unit activity
of somatosensory zone I and inhibition of neuron responses to somatic stimulation. This property of the preparation is believed
to form the basis of its antimotion effect.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No. 5, pp. 515–516, May, 1995
Presented by P. V. Sergeev, Member of the Russian Academy of Medical Sciences |
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Keywords: | nooglutyl motion sickness cortical neurons |
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