| 大肠癌组织中p53蛋白和MAD2蛋白表达及意义 |
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| 引用本文： | 李刚强,张洪福.大肠癌组织中p53蛋白和MAD2蛋白表达及意义[J].安徽医科大学学报,2002,37(3):191-193. |
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| 作者姓名： | 李刚强 张洪福 |
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| 作者单位： | 安徽医科大学病理学教研室,合肥,230032 |
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| 基金项目： | 安徽省自然科学基金资助课题 (编号 :0 10 43 717) |
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| 摘 要： | 目的研究大肠癌组织中p53、MAD2基因的表达及意义.方法应用免疫组化SP方法检测40例大肠癌组织中基因p53、MAD2的表达.结果正常黏膜p53表达阴性,腺癌表达率为55%,两者差异有显著性(P＜0.01).正常黏膜中MAD2蛋白表达阳性率为50%,腺癌中MAD2阳性率为85%,两者差异有显著性(P＜0.01),MAD2表达与大肠癌组织分化无关(P＜0.05).结论p53基因突变及MAD2基因异常在大肠癌发生中起重要作用.
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| 关 键 词： | 结肠直肠肿瘤/遗传学 基因 p53 免疫组织化学自由词 MAD2 |
| 文章编号： | 1000-1492(2002)03-0191-03 |
| 修稿时间： | 2002年1月16日 |
Expression of p53 and MAD2 in colorectal cancer and its significances |
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| Li Gangqiang,Zhang Hongfu.Expression of p53 and MAD2 in colorectal cancer and its significances[J].Acta Universitis Medicinalis Anhui,2002,37(3):191-193. |
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| Authors: | Li Gangqiang Zhang Hongfu |
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| Abstract: | Objective To study the expression of p53 and MAD2 in colorectal cancer and their significance. Methods The expression of p53 and MAD2 was detected by immunohistochemistry SP method in 40 colorectal cancer. Results No such protein expressions were observed in normal mucosa.The rate of p53 positive expression in adenocarcinomas was 55%. There was significant difference between colorectal normal mucosa and colorectal adenocarcinomas( P <0.01). The rates of MAD2 positive expression in colorectal musoca and its adenocarcinomas were 50% and 85% respectively. There was significant difference between colorectal normal mucosa and colorectal adenocarcinomas ( P <0 01),and it was not related to the differentiation of adenocarcinomas( P <0 05). Conclusion Alteration of p53 gene and MAD2 gene is involved mainly in colorectal carcinogenesis. |
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| Keywords: | colorectal neoplasms/genetics gene p53 immunohistochemistry |
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