| 灯盏乙素在小鼠体内药物动力学研究 |
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| 引用本文： | 丁存刚,葛庆华. 灯盏乙素在小鼠体内药物动力学研究[J]. 中国医药工业杂志, 2006, 37(1): 26-31 |
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| 作者姓名： | 丁存刚 葛庆华 |
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| 作者单位： | 上海医药工业研究院,上海,200437 |
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| 摘 要： | 研究了灯盏乙素及其新发现的一代谢物在小鼠体内的药物动力学性质，并采用HPLC—DAD和LC—MS/MS分析该代谢物的结构。初步推定这一代谢物是由灯盏乙素再结合一分子葡糖醛酸组成，分了式C27H26O18最大紫外吸收波长334和271nm。
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| 关 键 词： | 灯盏乙素 灯盏花素 药物动力学 葡糖醛酸化物 高效液相色谱 色谱-质谱 |
| 文章编号： | 1001-8255（2006）01-0026-06 |
| 收稿时间： | 2005-11-14 |
| 修稿时间： | 2005-11-14 |
Pharmacokinetics of Scutellarin in Mice |
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| DING Cun-Gang,GE Qing-Hua. Pharmacokinetics of Scutellarin in Mice[J]. , 2006, 37(1): 26-31 |
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| Authors: | DING Cun-Gang GE Qing-Hua |
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| Affiliation: | Shanghai Institute of Pharmaceutical Industry, Shanghai 200437 |
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| Abstract: | The pharmacokinetics properties of scutellarin and one of its newly found metabolite in mice was studied. The structure of the metabolite was elucidated with HPLC-DAD and LC-MS/MS methods. It was proposed primarily that the metabolite was an equimolecular combination of scutellarin and glycuronic acid, with molecular formula of C27H26O18 and Emax of 334 and 271nm. |
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| Keywords: | scutellarin breviscapine pharmacokinetics glucuronide HPLC LC-MS/MS |
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