丹参多酚酸盐治疗急性脑缺血的临床研究

目的探讨丹参多酚酸盐治疗急性脑缺血患者的临床疗效。方法将96例急性脑缺血患者随机分为治疗1组、治疗2组、对照组,各32例,对照组采用常规治疗:抗血小板、脑保护剂及改善脑循环、血压控制等;治疗1组在常规治疗的基础上加用丹参多酚酸盐100 mg/d静脉滴注,共治疗14 d;治疗2组在常规治疗的基础上加用丹参多酚酸盐200 mg/d静脉滴注,共治疗14 d。测定治疗前后三组患者的神经功能缺失评分(NDS)和日常生活活动能力评分(ADL)。结果治疗1组治疗前后NDS为(21.65±3.75)、(17.75±2.74)分,治疗2组为(21.28±4.08)、(15.43±3.057)分,对照组为(21.50±3.66)、(18.53±3.63)分,三组NDS均降低(P<0.05),且治疗2组改善情况优于对照组(P<0.05)。治疗1组治疗前后ADL评分分别为(24.21±3.12)、(58.23±5.31)分,治疗2组为(28.25±4.82)、(59.23±8.54)分,对照组为(29.53±4.51)、(55.78±8.55)分。三组治疗后ADL评分明显升高,但治疗2组较对照组升高明显(P<0.05)。治疗2组总有效率(90.62%)高于对照组(68.75%)(P<0.05)。结论中剂量丹参多酚酸盐可显著改善急性脑缺血患者的病情,值得临床推广。

Clinical study of salt from salvia miltiorrhiza on patients with acute cerebral ischemia

Objective To investigate the clinical effect of salt from salvia miltiorrhiza on patients with acute cerebral ischemia.Methods 96 patients with acute cerebral ischemia were randomly divided into 3 groups,group 1(n=32,miltiorrhiza 100 mg/d),group 2(n=32,miltiorrhiza 200 mg/d)and control group(n=32).All the groups were treated with routine treatment of antiplatelet,brain protestant,brain circulation improvement and blood pressure control.The treatment lasted for 14 d.Before and l4 d after treatment,the neurologic impairment analysis,activity of daily living scale(ADL)were checked.Results After treatment,the NDS of group 1,group 2 and control group decreased from(21.65±3.75),(21.28±4.08),(21.50±3.66) to(17.75±2.74),(15.43±3.057),(18.53±3.63) respectively(P<0.05),in which,the improvement of group 2 was better than that of control group(P<0.05);the ADL of group 1,group 2 and control group increased from(24.21±3.12),(28.25±4.82),(29.53±4.51) to(58.23±5.31),(59.23±8.54),(55.78±8.55) respectively(P<0.05),and the increase of group 2 was more significant than that of control group(P<0.05).There was significant difference in total effective rate between group 2 and control group(90.62% vs.68.75%,P<0.05).Conclusion Mid-dose of salt from salvia miltiorrhiza can improve the symptom of patients with acute cerebral ischemia.