| 大、小鼠摄入AFB_1和羧乙基锗倍半氧化物体内超氧化物歧化酶变化研究 |
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| 引用本文： | 侯华新,黎丹戎,秦箐,涂文升,刘宗河.大、小鼠摄入AFB_1和羧乙基锗倍半氧化物体内超氧化物歧化酶变化研究[J].肿瘤防治研究,1996(6). |
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| 作者姓名： | 侯华新 黎丹戎 秦箐 涂文升 刘宗河 |
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| 作者单位： | 广西医科大学，广西肿瘤防治研究所 |
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| 摘 要： | 本实验通过观察摄入ＡＦＢ１及Ｇｅ－１３２后Ｗｉｓｔａｒ大鼠和昆明小鼠体内ＳＯＤ活力的变化，进一步了解ＡＦＢ１代谢途径和Ｇｅ－１３２与自由基的关系。实验表明，摄入ＡＦＢ１的ＳＯＤ活力受到抑制，而摄入Ｇｅ－１３２后ＳＯＤ活力得到提高，且一次性摄入ＡＦＢ１后ＳＯＤ活力最终得到恢复，其中大鼠对ＡＦＢ１敏感性相对较大。
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| 关 键 词： | 黄曲霉毒素B＿1 羧乙基锗倍半氧化物 超氧化物歧化酶 |
Study on the Change Tendency or SOD Activity in Wistar Rats and Kunming Mice after dietary Arlatoxin B_1 and Ge-132 |
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| Hou huaxin,et al.Study on the Change Tendency or SOD Activity in Wistar Rats and Kunming Mice after dietary Arlatoxin B_1 and Ge-132[J].Cancer Research on Prevention and Treatment,1996(6). |
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| Authors: | Hou huaxin |
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| Abstract: | In order to investigate AFB1metabolic pathway in vivo and relationship between Ge-132 and the free radical, the SOD activity in Wistar rats and Kunming mices. which had been intaken AFB, and Ge-132 before and after were determined.The results showed that the changing tendency of SOD in rats and mices was lar. AFB, could signficantly reduce the SOD activity in red blood cell, serum and liver tissue. The SOD activity both in rats and mices was stimulated after intaken Ge-132. Inhibitory of the SOD activity by single injection AFB, graduated away at last. Wistar rats were more sensitive to AFB, than Kunming mices. |
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| Keywords: | Aflatoxin B_1 (AFB_1 ) Carboxyethylgermanium (Ge-132) Superoxide Dismutase(SOD) |
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