| 91例急性白血病患者骨髓单个核细胞CD96分子的表达研究 |
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| 引用本文： | Wu Y,Xiao M,Zhu L,Zhou XX,Gong Q,Xin X,Li CR,Zhou JF,Deng JN. 91例急性白血病患者骨髓单个核细胞CD96分子的表达研究[J]. 中国实验血液学杂志, 2011, 19(3): 585-588 |
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| 作者姓名： | Wu Y Xiao M Zhu L Zhou XX Gong Q Xin X Li CR Zhou JF Deng JN |
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| 作者单位： | 华中科技大学同济医学院附属同济医院血液内科,湖北武汉,430030 |
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| 基金项目： | 国家自然科学基金,编号30800402; 科技部重大新药创制、科技重大专项十一五课题,编号2009zx09103-740 |
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| 摘 要： | 本研究旨在检测91例急性白血病患者骨髓单个核细胞(BMMNC)表面分子CD96的表达情况,并结合临床资料进行分析。采用流式细胞术检测91例初治急性白血病患者骨髓单个核细胞表面分子CD96,以15例健康成人作为对照组。结果表明:21例B-ALL患者BMMNC(CD45+CD34+CD19+)中CD96平均表达水平为(17.41±27.97)%,11例T-ALL患者BMMNC(CD45+CD34+CD7+)中CD96平均表达水平为(46.98±45.55)%,59例AML患者BMMNC(CD45+CD34+CD38-)中CD96平均表达水平为(16.69±25.08)%,与健康对照组BMMNC的CD96平均表达水平(0.52±1.84)%相比,差异有统计学意义(p<0.05);正规治疗后,CD96+及CD96-组的未缓解率(分别为52%,10.6%)差异有统计学意义(p<0.05);另外,复查治疗后CD96在BMMNC的平均表达水平显示,达到完全缓解的CD96+组为(1.68±2.31)%,与对照组比较,差异无统计学意义(p>0.05);而未达到完全缓解的CD96+组为(62.39±26.29)%,与对照组比较,...
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| 关 键 词： | 急性白血病 骨髓单个核细胞 CD96 |
CD96 expression on bone marrow mononuclear cells in 91 patients with acute leukemia |
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| Wu Ying,Xiao Min,Zhu Li,Zhou Xiao-Xi,Gong Quan,Xin Xing,Li Chun-Rui,Zhou Jian-Feng,Deng Jin-Niu. CD96 expression on bone marrow mononuclear cells in 91 patients with acute leukemia[J]. Journal of experimental hematology, 2011, 19(3): 585-588 |
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| Authors: | Wu Ying Xiao Min Zhu Li Zhou Xiao-Xi Gong Quan Xin Xing Li Chun-Rui Zhou Jian-Feng Deng Jin-Niu |
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| Affiliation: | WU Ying,XIAO Min,ZHU Li,ZHOU Xiao-Xi,GONG Quan,XIN Xing,LI Chun-Rui,ZHOU Jian-Feng,DENG Jin-Niu Department of Hematology,Tongi Medical College Tongji Hospital,Huazhong University of Science and Technology,Wuhan 430030,Hubei Province,China |
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| Abstract: | This study was aimed to investigate the expression of CD96 on bone marrow mononuclear cells(BMMNC) from 91 patients with acute leukemia,and the results were analyzed with clinical pathological data.Flow cytometry was used to detect CD96 molecule on the bone marrow mononuclear cell surface of 91 newly diagnosed patients with acute leukemia,and 15 healthy adults were served as normal controls.The results showed that the average rate of CD96+ expression on BMMNC(CD45+ CD34+ CD19+) of 21 patients with B-ALL was... |
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| Keywords: | leukemia leukemia stem cell CD96 |
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