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| 冠心病患者vWF基因A1381T多态性分析 | |
| 引用本文： | Yuan ZH,Hou YJ,Li Y,Zhang H,Li ZY,Li X,Yu DH. 冠心病患者vWF基因A1381T多态性分析[J]. 中国实验血液学杂志, 2011, 19(3): 775-780 |
| 作者姓名： | Yuan ZH Hou YJ Li Y Zhang H Li ZY Li X Yu DH |
| 作者单位： | 1. 吉林医药学院检验系血检教研室,吉林省吉林,132013 2. 吉林医药学院附属465医院检验科,吉林省吉林,132013 3. 吉林医药学院附属465医院心血管内科,吉林省吉林,132013 |
| 基金项目： | 本课题受吉林省教育厅科研基金资助,编号2009-510 |
| 摘 要： | 本研究探讨冠心病患者vWF基因A1381T多态性。采用酶联免疫吸附法测定104名40-75岁(平均59岁)连续住院的冠心病患者血浆vWF:Ag水平,同时测定96名39-70岁(平均56岁)同期门诊体检的人群血浆vWF:Ag水平作为对照组;采用PCR产物酶切片段长度分析vWF基因A1381T单核苷酸多态性,测序验证。实验数据根据对照组和冠心病组性别、血型或/和基因型进行分组,采用t检验、方差分析、χ2检验等统计学处理。结果表明:vWF基因A1381T多态性GG基因型的频率在冠心病组为62.5%,对照组为67.7%,而AG基因型在冠心病组为37.5%,对照组为32.3%。卡方检验显示,AG基因型与冠心病没有相关性,其优势比OR=1.258(95%CI=0.702-2.255,χ2=0.595,p=0.440)。冠心病组血浆vWF含量明显高于对照组(p<0.001),冠心病组AG和GG基因型的个体血浆vWF含量均明显高于对照组AG和GG型(p<0.001)。基因型AG与GG比较,在冠心病组中差异有统计学意义(p<0.05),即冠心病组AG个体血浆vWF含量明显高于GG个体,而对照组AG个体血浆vWF含量虽略有增高但... |
| 关 键 词： | vWF A1381T多态性 血型 冠心病 |
Analysis of vWF gene A1381T polymorphism in patients with coronary heart disease |
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| Yuan Zhong-Hai,Hou Yi-Ju,Li Yan,Zhang Hui,Li Zhong-Yan,Li Xin,Yu Dong-Hui. Analysis of vWF gene A1381T polymorphism in patients with coronary heart disease[J]. Journal of experimental hematology, 2011, 19(3): 775-780 | |
| Authors: | Yuan Zhong-Hai Hou Yi-Ju Li Yan Zhang Hui Li Zhong-Yan Li Xin Yu Dong-Hui |
| Affiliation: | YUAN Zhong-Hai,HOU Yi-Ju,LI Yan,ZHANG Hui1,LI Zhong-Yan2,LI Xin,YU Dong-Hui2 Section of Blood Examination,Department of Medical Laboratory Examination,Jilin Medical and Pharmaceutical College,Jilin 132013,Jilin Province,China,1Department of Laboratory Examination,2Department of Cardiovasology,The Affiliated Hospital 465,Jilin Medical and Pharmacentical College |
| Abstract: | This study was purposed to investigate the vWF gene A1381T polymorphism in patients with coronary heart disease(CHD).A case-control study was designed,including 104 continuously hospitalized patients with CHD,aging from 40 to 75 years(average 59) and 96 persons underwent physical examination in outpatient department as controls,aging from 39 to 70 years(average 56).The plasma vWF: Ag level of CHD patients and control persons was detected by ILISA.vWF gene A1381T polymorphism was analyzed by the polymerase c... |
| Keywords: | vWF A1381T polymorphism blood group coronary heart disease |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ | |