| ABO血型不合异基因造血干细胞移植对红系造血恢复的影响 |
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| 引用本文： | Cai XJ,Hong JY,Chen Y,Yu K. ABO血型不合异基因造血干细胞移植对红系造血恢复的影响[J]. 中国实验血液学杂志, 2011, 19(3): 801-804 |
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| 作者姓名： | Cai XJ Hong JY Chen Y Yu K |
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| 作者单位： | 1. 温州医学院附属第一医院输血科,浙江温州,325000
2. 温州医学院附属第一医院血液内科,浙江温州,325000 |
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| 摘 要： | 本研究探讨ABO血型不合异基因造血干细胞移植对红系造血的影响。对16例ABO血型不合的造血干移植患者的ABO血型,IgM和IgG抗体进行监测。结果显示,16例ABO血型不合的造血干细胞移植患者均恢复造血功能,与ABO血型相合组比较,ABO血型不合组在粒细胞植活时间、血小板植活时间无差异,但红系重建时间明显延长;ABO主侧不合与双侧不合受者抗供者凝集素消失时间与红系恢复时间有相关性。结论 :ABO血型不合的异基因造血干细胞移植会导致红系造血迟缓。移植前用供型血浆置换法或输注供者红细胞来中和受者体内抗供者红细胞的凝集素能缩短红细胞植入时间,减少红细胞的输注。
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| 关 键 词： | ABO血型不合 干细胞移植 |
Effect of ABO-incompatible allogeneic stem cell transplantation on erythroid lineage hematopoiesis |
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| Cai Xue-Jiao,Hong Jun-Yin,Chen Yi,Yu Kang. Effect of ABO-incompatible allogeneic stem cell transplantation on erythroid lineage hematopoiesis[J]. Journal of experimental hematology, 2011, 19(3): 801-804 |
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| Authors: | Cai Xue-Jiao Hong Jun-Yin Chen Yi Yu Kang |
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| Affiliation: | CAI Xue-Jiao,HONG Jun-Yin,CHEN Yi1,YU Kang1Department of Blood Transfusion,1Department of Hematology,The First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,Zhejiang Province,China |
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| Abstract: | This study was purposed to investigate the effect of ABO-incompatible allogeneic hematopoietic stem cell transplantation(allo-HSCT) on erythroid lineage hematopoiesis.The changes of ABO group,IgM and IgG antibody in 16 patients reveiced ABO-incompatible allo-HSCT were detected.The results showed that ABO-incompatible allo-HSCT were successfully engrafted in 16 patients,and there was no difference in reconstitution of platelets and neutrophils between ABO-incompatible and ABO-compatible transplantation(p>0.0... |
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| Keywords: | ABO compatibility stem cell transplantation |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
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