| 小鼠颈部心脏移植模型的改进 |
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| 引用本文： | 高思海,李平,潘铁成,杨辰垣. 小鼠颈部心脏移植模型的改进[J]. 广东医学, 2004, 25(7): 756-757 |
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| 作者姓名： | 高思海 李平 潘铁成 杨辰垣 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院胸心外科,武汉,430030;华中科技大学同济医学院附属协和医院心外科,武汉,430022 |
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| 基金项目： | 国家自然科学基金资助项目 (编号 :3 9670 72 0 ) |
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| 摘 要： | 目的 探讨小鼠颈部心脏移植模型的改进和研究心脏移植再灌注损伤及急性排异反应。方法 将Chen氏术式加以改进 ,将供心主动脉与受体颈总动脉行端侧吻合 ,进行 6 0次小鼠颈部心脏移植。结果 新方法使供心总缺血时间缩短至 30min ,7d存活率提高到 98%。结论 改进后的模型简单实用 ,提高了小鼠颈部心脏移植存活率 ,值得推广。
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| 关 键 词： | 心脏移植 异位移植 小鼠 |
| 修稿时间： | 2003-11-26 |
Improved technique of cervical heterotopic heart transplantation in mice |
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| Gao Sihai,Li Ping,Pan Tiecheng,et al.. Improved technique of cervical heterotopic heart transplantation in mice[J]. Guangdong Medical Journal, 2004, 25(7): 756-757 |
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| Authors: | Gao Sihai Li Ping Pan Tiecheng et al. |
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| Affiliation: | Gao Sihai,Li Ping,Pan Tiecheng,et al. Department of Thoracic and Cardiac Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 |
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| Abstract: | Objective To improve the technique of mouse cervical heterotopic heart transplantation and to study cardiac transplantation rejection and reperfusion injury. Methods By modifying Chen's method, the donor heart aorta and the right common carotid artery of the recipient were anastomosed using the end-to- side suture technique. Results The total ischeamic time of the graft shortened to 30 min and the 7 day survival rate of the recipient increased to 98% by using the new technique. Conclusions The development of cervical heart transplantation in mice is a novel, simple and useful technique. |
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| Keywords: | Heart transplantation Heterotopic transplantation Mice |
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