窒息新生儿并发脑损伤相关因素分析

目的 探讨窒息新生儿发生脑损伤相关因素,为临床诊治提供参考依据。 方法 对2010 年11月-2011年6月入住北京军区总医院附属八一儿童医院治疗的102例窒息新生儿临床资料进行回顾性分析。 结果 102例窒息新生儿中,46例发生脑损伤,发生脑损伤组(n=46)与未发生脑损伤组(n=56)对比发现,并发脑损伤组患儿胎龄、脐带异常、胎盘早剥、羊水污染、胎心异常和孕母妊高症均明显高于未发生脑损伤组(P<0.05)。Logistic回归分析显示:胎龄、脐带异常、胎盘早剥、羊水污染、孕母妊高症均与窒息新生儿并发脑损伤密切相关。 结论 对于具有上述危险因素的窒息新生儿,应及时给予干预和复苏,减少脑损伤的发生。

Correlation analysis of perinatal hypoxic ischemic brain damage

Objective To explore the risk factors for perinatal hypoxic ischemic brain damage in asphyxiated newborn infants. Method A retrospective study was carried out in 102 asphyxiated newborn infants from Nov.2010 to the end of Jun.2011 in Bayi Children's Hospital Affiliated to General Hospital of Beijing Military Command of People's Liberation Army. Results In 102 asphyxiated newborn infants,46 new born infants were complicated with hypoxic ischemic brain damage(HIBD).The clinical data of the HIBD group (n=46) were compared with those of the HIBD negative group (n=56).The gestational age,umbilical cord abnormalities,placental abruption,meconium,abnormal fetal heart rate and hypertensive disorders in pregnancy were more common in the perinatal HIBD group (P<0.05).Logistic regression analysis showed gestational age,umbilical cord abnormalities,placental abruption,meconium and hypertensive disorders in pregnancy were the risk factors of HIBD in asphyxiated new born infants. Conclusion Asphyxiated newborn infants with the above mentioned risk factors should be given with appropriate intervention and resuscitation,thereby may prevent the perinatal asphyxia and minimize the occurrence of HIBD.