Susceptibility genes for schizophrenia |
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| Authors: | RYOTA HASHIMOTO md phd SATOKO HATTORI p hd SACHIE CHIBA ms c YUKI YAGASAKI ms c TAKEYA OKADA p hd EMI KUMAMARU p hd TAKEYUKI MORI md KIYOTAKA NEMOTO md HISASHI TANII md phd HIROAKI HORI md HIROKO NOGUCHI ma TADAHIRO NUMAKAWA p hd TAKASHI OHNISHI md phd AND HIROSHI KUNUGI md phd |
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| Affiliation: | Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry,;Department of Radiology, National Center Hospital of Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo, Japan and;Department of Psychiatry, Mie University, Mie, Japan |
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| Abstract: | Abstract It is well known that genetic factors contribute to the susceptibility for schizophrenia. Recent advances in the molecular genetics of schizophrenia strongly suggest several susceptibility genes (e.g. dysbindin, neuregulin-1, DISC1, COMT, G72, RGS4 and Akt1). We discuss the evidence and biology of these genes. As glutamate transmission is especially implicated in these genes, neurobiological basis of schizophrenia might be elucidated by investigation of functional interactions between susceptibility genes for schizophrenia and the glutamatergic system. |
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| Keywords: | COMT DISC1 dysbindin neuregulin-1 schizophrenia susceptibility gene |
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