Human herpesviruses-6, -7 and -8 in organ transplant recipients |
| |
Authors: | N. Singh |
| |
Affiliation: | Veterans Affairs Medical Center and University of Pittsburgh, Thomas E. Starzl Transplantation Institute, Pittsburgh, Pennsylvania, USA |
| |
Abstract: | The newer herpesviruses are being increasingly recognized as significant opportunistic pathogens in organ transplant recipients. Published data support the role of human herpesvirus-6 as a potential cause of encephalitis and bone marrow suppression in transplant setting. An association of human herpesvirus-6 with fungal infections and cytomegalovirus infection has also been documented. Human herpesvirus-7 also appears to be an immunomodulatory agent and may facilitate the pathogenicity of cytomegalovirus. Unlike human herpesviruses -6 and -7, human herepsvirus -8 is not ubiquitous; its seroprevalence exhibits wide geographic variation. Human herpesvirus-8 has been causally associated with post-transplant Kaposi's sarcoma. The complete spectrum of pathogenicity and ultimately the effective prophylaxis and management of these viruses has yet to be fully elucidated. |
| |
Keywords: | transplantation herpesviruses human herpesvirus-6 human herpesvirus-7 human herpesvirus-8 Kaposi's sarcoma herpesvirus |
本文献已被 ScienceDirect 等数据库收录! |