鲍曼不动杆菌的临床分布及耐药性变迁

目的了解鲍曼不动杆菌在临床标本的分离率和病区分布及耐药性变化趋势。方法菌株鉴定采用法国梅里埃VITEK32细菌鉴定系统进行鉴定,药敏试验采用K-B法,药敏试验结果判定以CLSI/NCCLS标准进行。结果 2004-2010年共收到26670份标本,分离出阳性细菌7065株,其中鲍曼不动杆菌471株（6.67%）,分离率为1.77%（471/7065）。在471株鲍曼不动杆菌中,从痰液标本分离出最多有409株（86.83%）,分离率最高的是ICU,占49.3%。鲍曼不动杆菌对抗菌药物的耐药性普遍较高,且呈逐年升高趋势,部分表现出多重耐药特征。结论鲍曼不动杆菌的耐药状况日益严重,应重视临床鲍曼不动杆菌的感染与分离,谨防多重耐药鲍曼不动杆菌的院内感染及暴发流行。

Clinical distribution and drug resistance of Acinetobacter baumannii

Objective To investigate the isolation rate,distribution and trend of drug resistance of Acinetobacter baumannii from 2004 to 2010.Methods French bioMerieux VITEK32 bacterial identification system was used for identification.The K-B method was used for drug sensitivity test and the results of drug sensitivity test was determined using the CLSI /NCCLs standard.Results 26 670 specimens were analyzed from 2004 to 2010.7 065 bacterial strains isolated from the positive samples,of which 6.67%（471 /7 065） was Acinetobacter baumannii strains.The isolation rate of Acinetobacter baumannii was 1.77%.409 strains were isolated from sputum samples accounted for 86.83% of the total number of Acinetobacter baumannii isolates.The isolation rate is the highest in the ICU ward（49.3%）.Acinetobacter baumannii resistance to antimicrobial drugs is generally higher,and showing a trend of increasing,and some exhibit multidrug resistance characteristics.Conclusion There is a trend of increase in drug resistance in Acinetobacter baumannii.We should pay attention to clinical Acinetobacter baumannii infection and separation;beware of multi-resistance in Acinetobacter baumannii nosocomial infections and outbreaks.