老年戊型肝炎患者NO及脂质过氧化的研究

目的 探讨老年戊型肝炎患者血清ＮＯ、ＭＤＡ、ＳＯＤ与发病的关系。方法 采用Ｇｒｉｅｒｓ比色法测定ＮＯ，以ＴＢＡ法测定ＭＤＡ，以分光光度法测定ＳＯＤ。结果 老年戊型肝炎患者血清ＮＯ、ＭＤＡ浓度明显高于正常老年对照组（Ｐ〈０．０５），ＳＯＤ明显低于正常老年对照组（Ｐ〈０．０５）。血清胆红素〉８５．５ｎｍｏｌ／Ｌ者表ＮＯ之间差异无显著性，而血清ＭＤＡ、ＳＯＤ差异有显著性（Ｐ〈０．０５￣０．０１）。发生重

Study on NO, MDA and SOD in aged patients with hepatitis E

Aim To determine the effect of NO, MDA and SOD on pathogeny of hepatitis E in aged patients. Methods NO was detected by Griers colorimetry, MDA by TBA method and SOD by spectrophotometry. The serum levels of NO, MDA and SOD were detected in 50 aged patients with hepatitis E. Results The level of SOD was significantly lower (P < 0.05), while NO and MDA were higher (P < 0. 05 ) than those in normal aged controls. There was a postivve correlation between MDA and total bilirubin (TBil) (P < 0.05). There was also a negative correlation between SOD and TBil(P < 0.05). The levels of SOD and NO were significantly low while MDA were elevated in patients who had developed into serious hepatitis (P < 0.05 ~ 0.01 ). There was a postitve correlation between NO and SOD(P < 0 .01 ). There were negative correlations between MDA and NO (P < 0.05) and between MDA and SOD (P < 0.05). Conclusions These results suggested there were unbalance between Oxidation and anti-oxidation which play a role in the pathogeny in aged patients with hepatitis E. MDA and SOD may be as markers which can judge the degree of hepatic injury and prognosis in aged patients with hepatitis E.