| 动脉粥样硬化患者PBMC MCP-1基因表达及其临床意义 |
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| 引用本文： | 陈平,陈立强,梁结玲,李承德,蔡健梅,吴小文,刘健,梁洁玲. 动脉粥样硬化患者PBMC MCP-1基因表达及其临床意义[J]. 医学检验与临床, 2013, 0(4): 1-2,9 |
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| 作者姓名： | 陈平 陈立强 梁结玲 李承德 蔡健梅 吴小文 刘健 梁洁玲 |
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| 作者单位： | 肇庆市第一人民医院检验科,广东肇庆526021 |
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| 摘 要： | 目的：研究动脉粥样硬化（Atherosclerosis，AS）患者外周血单个核细胞（peripheral blood mononuclear cells，PBMC）的趋化因子蛋白-1（Monocyte Chemoattractant Protein-1，MCP-1）的基因表达及其临床意义。方法：采用RT-PCR检测20例动脉粥样硬化患者和20例健康者PBMC MCP-1的基因表达。结果：动脉粥样硬化患者PBMC MCP-1基因表达明显高于健康者，差异有统计学意义（P〈0.05）。结论：MCP-1表达与动脉粥样硬化存在一定相关性，在动脉粥样硬化发病过程中起重要的作用。
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| 关 键 词： | 动脉粥样硬化 趋化因子蛋白-1 外周血单个核细胞 逆转录聚合酶链反应 |
PBMC MCP-1 gene expression and its clinical significance in atherosclerosis patients |
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| Chen Ping,CHEN Li-qiang,LIANG Jie-ling. PBMC MCP-1 gene expression and its clinical significance in atherosclerosis patients[J]. Medical Laboratory Science and, 2013, 0(4): 1-2,9 |
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| Authors: | Chen Ping CHEN Li-qiang LIANG Jie-ling |
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| Affiliation: | , LI cheng-de, CAI Jian-mei, WU Xiao-wen, LiuJian, LIANG Jie-ling (Department of Clinical Laboratory, the First People ＇ s Hospital of Zhaoqing 526021, China) |
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| Abstract: | Objective：To study the gene expression and clinical significance of Monocyte chemoatlactant Protein-1（MCP-1） in peripheral blood mononudear cells（PBMCS） of Atherosclerosis（AS）. Methods：Gene expression of MCP-1 in PBMCS was detected by RT-PCR in both 20 cases of AS and 20 healthy controls.Results：Gene expression of MCP-1 in PBMCS of patients with As was significantly higher thew that of controls（P〈0.05）Conclusions：MCP-1 expression in PBMCs was releted to As and may play an importawt role in the course of disease. |
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| Keywords: | Atherosclerosis MCP-1 PBMC RT-PCR |
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