| 恩替卡韦与阿德福韦酯治疗拉米夫定耐药慢性乙肝患者效果的比较 |
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| 引用本文： | 赵攀,徐东平,管群.恩替卡韦与阿德福韦酯治疗拉米夫定耐药慢性乙肝患者效果的比较[J].热带医学杂志,2011,11(1):63-64,81. |
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| 作者姓名： | 赵攀 徐东平 管群 |
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| 作者单位： | 解放军第302医院病毒性肝炎研究室,北京,100039 |
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| 摘 要： | 目的比较恩替卡韦与阿德福韦酯治疗拉米夫定耐药慢性乙型肝炎患者的效果。方法检索2010年6月以前公开发表的有关恩替卡韦(剂量1mg/d)与阿德福韦酯(剂量10mg/d)治疗拉米夫定耐药慢性乙型肝炎患者(疗程≥48周)的随机对照临床研究。采用χ2检验分析研究间的异质性,以相对危险度为疗效分析统计量进行合并分析并绘制森林图。疗效判定指标为血清HBVDNA检测不到(阴转)。结果 Meta分析结果显示,阿德福韦酯与恩替卡韦对拉米夫定耐药株的疗效差异有统计学意义(Z=2.26,P=0.02),相对危险度的95%置信区间为0.51～0.95。结论恩替卡韦(1mg/d)治疗拉米夫定耐药患者的48周疗效(血清HBVDNA阴转率)好于阿德福韦酯(10mg/d)。
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| 关 键 词： | 慢性乙型肝炎 恩替卡韦 阿德福韦酯 拉米夫定 耐药 |
Comparison of efficacy between entecavir and adefovir dipivoxil in lamivudine-refractory patients with chronic hepatitis B |
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| ZHAO Pan,XU Dong-ping,GUAN Qun.Comparison of efficacy between entecavir and adefovir dipivoxil in lamivudine-refractory patients with chronic hepatitis B[J].Journal Of Tropical Medicine,2011,11(1):63-64,81. |
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| Authors: | ZHAO Pan XU Dong-ping GUAN Qun |
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| Institution: | ZHAO Pan,XU Dong-ping,GUAN Qun(Viral Hepatitis Research Laboratory of 302 Hospital,Beijing 100039,China) |
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| Abstract: | Objective To evaluate the efficacy of entecavir and adefovir dipivoxil in lamivudine-refractory patients with chronic hepatitis B.Methods Both Chinese and English articles published before June 2010 about the efficacy of entecavir and adefovir dipivoxil in lamivudine-refractory patients with chronic hepatitis B were searched and analyzed.The dosages of entecavir and adefovir dipivoxil used in the patients for over 48 weeks were 1 mg/d and 10 mg/d,respectively.Heterogeneity was examined by Chi-square test,th... |
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| Keywords: | chronic hepatitis B entecavir adefovir dipivoxil lamivudine resistance |
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