| 正交试验优选复方酮康唑凝胶剂的基质配比 |
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| 引用本文： | 杨盼鑫,黄文涛. 正交试验优选复方酮康唑凝胶剂的基质配比[J]. 中国药师, 2014, 0(6): 958-961 |
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| 作者姓名： | 杨盼鑫 黄文涛 |
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| 作者单位： | 武汉市中西医结合医院药学部制剂中心 武汉 430022;武汉市中西医结合医院药学部制剂中心 武汉 430022 |
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| 基金项目： | 武汉市卫生局课题（编号：WX13D01） |
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| 摘 要： | 目的：优选复方酮康唑凝胶剂的最佳基质配比.方法：通过正交试验设计,利用溶解扩散模型筛选出最佳基质配比,并以HPLC法同时测定酮康唑和硝酸咪康唑的含量.结果：最佳凝胶基质配比为卡波姆-940 0.3％、甘油30％、聚乙二醇400 10％.结论：凝胶基质配比合理,凝胶中酮康唑和硝酸咪康唑的单位面积累计渗透量均值同为最大值.
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| 关 键 词： | 正交试验设计 酮康唑 硝酸咪康唑 凝胶剂 |
| 收稿时间： | 2014-01-02 |
| 修稿时间： | 2014-03-18 |
Optimization of Base Ratio for Compound Ketoconazole Gels by Orthogonal Experimental Design |
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| Yang Panxin and Huang Wentao. Optimization of Base Ratio for Compound Ketoconazole Gels by Orthogonal Experimental Design[J]. China Pharmacist, 2014, 0(6): 958-961 |
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| Authors: | Yang Panxin and Huang Wentao |
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| Affiliation: | Department of Pharmacy of Wuhan Integrated TCM &Western Medicine Hospital, Wuhan 430022, China;Department of Pharmacy of Wuhan Integrated TCM &Western Medicine Hospital, Wuhan 430022, China |
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| Abstract: | Objective：To select the optimal base ratio for compound ketoconazole gels.Methods：Using orthogonal experimental design,the optimal base ratio was screened by solution-diffusion model,and two components （ketoconazole and miconazole nitrate） in the gels were simultaneously determined by HPLC.Results：The optimal base ratio was 0.3% carbomer-940,30% glycerol and 10%polyethylene glycol 400.Conclusion：The established formula is reasonable,and the average accumulative permeation per unit area of both ketoconazole and miconazole nitrate reaches maximum in the gels. |
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| Keywords: | Orthogonal experimental design Ketoconazole Miconazole nitrate Gels |
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