| 硫磺熏蒸金银花中断马钱子酸亚硫酸衍生物产生的机制探讨 |
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| 引用本文： | 郭爱丽,高慧敏,陈两绵,张启伟,王智民. 硫磺熏蒸金银花中断马钱子酸亚硫酸衍生物产生的机制探讨[J]. 中国中药杂志, 2014, 39(9): 1639-1643 |
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| 作者姓名： | 郭爱丽 高慧敏 陈两绵 张启伟 王智民 |
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| 作者单位： | 首都医科大学 中医药学院, 北京 100069;中国中医科学院 中药研究所, 北京 100700;中药质量控制技术国家工程实验室, 北京 100700;中国中医科学院 中药研究所, 北京 100700;中药质量控制技术国家工程实验室, 北京 100700;中国中医科学院 中药研究所, 北京 100700;中药质量控制技术国家工程实验室, 北京 100700;中国中医科学院 中药研究所, 北京 100700;中药质量控制技术国家工程实验室, 北京 100700;中国中医科学院 中药研究所, 北京 100700;中药质量控制技术国家工程实验室, 北京 100700 |
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| 基金项目： | 国家自然科学基金项目（81274079）；国家重点基础研究发展计划（973）项目（2012CB724001）；中医药行业科研专项（201307008-04）；国家“十二五”科技支撑计划项目（2011BAI06B01）；中国中医科学院中药研究所自主选题项目（2011LHXZ-01） |
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| 摘 要： | 为了探讨硫磺熏蒸金银花中断马钱子酸亚硫酸衍生物的生成机制,该研究采用柱色谱技术从未硫熏金银花中目标性制备分离了断马钱子酸以进行后续模拟反应,断马钱子酸在有水条件下与二氧化硫反应生成了其亚硫酸衍生物,反应机制可能涉及了断马钱子酸的酯化反应或者是酸化开环后亚硫酸根对羰基的加成反应。该研究为支持硫磺熏蒸导致金银花中断马钱子酸转变成其亚硫酸衍生物提供了实验依据。
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| 关 键 词： | 硫磺熏蒸 金银花 断马钱子酸 |
| 收稿时间： | 2014-02-24 |
Investigation on formation mechanism of secologanic acid sulfonates in sulfur-fumigated buds of Lonicera japonica |
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| GUO Ai-li,GAO Hui-min,CHEN Liang-mian,ZHANG Qi-wei and WANG Zhi-min. Investigation on formation mechanism of secologanic acid sulfonates in sulfur-fumigated buds of Lonicera japonica[J]. China Journal of Chinese Materia Medica, 2014, 39(9): 1639-1643 |
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| Authors: | GUO Ai-li GAO Hui-min CHEN Liang-mian ZHANG Qi-wei WANG Zhi-min |
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| Affiliation: | School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;National Engineering Laboratory of Quality Control Technology of Chinese Herbal Medicines, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;National Engineering Laboratory of Quality Control Technology of Chinese Herbal Medicines, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;National Engineering Laboratory of Quality Control Technology of Chinese Herbal Medicines, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;National Engineering Laboratory of Quality Control Technology of Chinese Herbal Medicines, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;National Engineering Laboratory of Quality Control Technology of Chinese Herbal Medicines, Beijing 100700, China |
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| Abstract: | To investigate formation mechanism of secologanic acid sulfonates in sulfur-fumigated buds of Lonicera japonica, secologanic acid was enriched and purified from the sun-dried buds of L.japonica by various column chromatography on macroporus resin HPD-100, silica gel and ODS.The stimulation experiments of sulfur-fumigation process were carried out using secologanic acid reacted with SO2 in the aqueous solution.The reaction mechanism could be involved in the esterification or addition reaction.The present investigation provides substantial evidences for interpreting formation pathway of secologanic acid sulfonates in sulfur-fumigated buds of L.japonica. |
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| Keywords: | sulfur-fumigation Lonicera japonica secologanic acid |
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