| 降香的化学成分研究 |
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| 引用本文： | 王昊,梅文莉,郭志凯,夏占峰,钟惠民,戴好富.降香的化学成分研究[J].中国中药杂志,2014,39(9):1625-1629. |
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| 作者姓名： | 王昊 梅文莉 郭志凯 夏占峰 钟惠民 戴好富 |
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| 作者单位： | 中国热带农业科学院 热带生物技术研究所 农业部热带作物生物学与遗传资源 利用重点实验室, 海南 海口 571101;青岛科技大学 化学与分子工程学院, 山东 青岛 266042;中国热带农业科学院 热带生物技术研究所 农业部热带作物生物学与遗传资源 利用重点实验室, 海南 海口 571101;海南省黎药资源天然产物研究与利用重点实验室, 海南 海口 571101;中国热带农业科学院 热带生物技术研究所 农业部热带作物生物学与遗传资源 利用重点实验室, 海南 海口 571101;海南省黎药资源天然产物研究与利用重点实验室, 海南 海口 571101;中国热带农业科学院 热带生物技术研究所 农业部热带作物生物学与遗传资源 利用重点实验室, 海南 海口 571101;海南省黎药资源天然产物研究与利用重点实验室, 海南 海口 571101;青岛科技大学 化学与分子工程学院, 山东 青岛 266042;中国热带农业科学院 热带生物技术研究所 农业部热带作物生物学与遗传资源 利用重点实验室, 海南 海口 571101;海南省黎药资源天然产物研究与利用重点实验室, 海南 海口 571101 |
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| 基金项目： | 国家“十二五”科技支撑计划项目（2013BAI11B04）；公益性行业（农业）科研专项（201303117）；海南省重大科技项目（ZDZX2013008-4） |
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| 摘 要： | 为了研究降香乙醇提取物的化学成分,采用硅胶柱色谱与Sephadex LH-20凝胶柱色谱进行分离纯化,并根据波谱数据进行结构鉴定。从降香中分离得到14个化合物,经波谱分析鉴定为3-羟基-4,9-二甲氧基紫檀烷(1),medicarpin(2),2’,4’,5-trihydroxy-7-methoxyisoflavone(3),7,2’,3’-三羟基-4’-甲氧基异黄烷(4),formononetin(5),3,8-dihydroxy-9-methoxypterocarpan(6),koparin(7),3-hydroxy-9-methoxypterocarp-6a-ene(8),2’-hydroxyformononetin(9),stevenin(10),2’,7-dihydroxy-4’,5’-dimethoxyisoflavone(11),lyoniresinol(12),2,5-dihydroxy-5-methoxy-benzo-phenone(13)和neokhriol A(14)。化合物1,3,4,6,8,12和14均为首次从降香中分离得到,滤纸片琼脂扩散法表明化合物4对烟草青枯菌有显著的抑制活性。
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| 关 键 词： | 降香 化学成分 抑菌活性 烟草青枯菌 |
| 收稿时间： | 2013/11/8 0:00:00 |
Chemical constituents of Dalbergia odorifera |
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| WANG Hao,MEI Wen-li,GUO Zhi-kai,XIA Zhan-feng,ZHONG Hui-min and DAI Hao-fu.Chemical constituents of Dalbergia odorifera[J].China Journal of Chinese Materia Medica,2014,39(9):1625-1629. |
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| Authors: | WANG Hao MEI Wen-li GUO Zhi-kai XIA Zhan-feng ZHONG Hui-min and DAI Hao-fu |
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| Institution: | Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China;Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Haikou 571101, China;Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Haikou 571101, China;Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Haikou 571101, China;College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China;Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Haikou 571101, China |
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| Abstract: | Fourteen compounds were isolated from Dalbergia odoriferae and purified by repeated column chromatography on silica and sephadex LH-20 gel and structurally identified by spectral analysis.These compounds were identified as 4, 9-dimethoxy-3-hydroxypterocarpan(1), medicarpin(2), 2', 4', 5-trihydroxy-7-methoxyisoflavone(3), 2', 3', 7-trihydroxy-4'-methoxyisoflavan(4), formononetin(5), 3, 8-dihydroxy-9-methoxypterocarpan(6), koparin(7), 3-hydroxy-9-methoxypterocarp-6a-ene(8), 2'-hydroxyformononetin(9), stevenin(10), 2', 7-dihydroxy-4', 5'-dimethoxyisoflavone(11), lyoniresinol(12), 2, 4-dihydroxy-5-methoxy-benzo-phenone(13)and neokhriol A(14).Compounds 1, 3, 4, 6, 8, 12 and 14 were isolated from this plant for the first time.Antibacterial activity assay showed that compound 4 had inhibitory effect on Ralstonia solanacearum. |
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| Keywords: | Dalbergia odorifera chemical constituent antibacterial activity Ralstonia solanacearum |
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