地屈孕酮治疗先兆流产388例疗效观察

目的：探讨地屈孕酮在先兆流产治疗中的临床作用.方法：776例先兆流产孕妇采用随机数表法分为两组,每组388例.所有孕妇均卧床充分休息,加强营养.对照组患者予口服黄体酮胶囊100 mg,po,bid,连续服用7d.观察组患者给予地屈孕酮口服,首剂40 mg,后每12 h 10 mg,连续服用7d.比较治疗前后两组患者的血清孕酮值、临床症状缓解时间、观察两组临床疗效及不良反应发生情况.结果：治疗后,观察组孕妇血清孕酮值显著高于对照组,临床症状缓解时间显著短于对照组（P＜0.05）.对照组保胎成功率82.98％,低于观察组的保胎成功93.81％ （P ＜0.05）.对照组不良反应发生率为6.19％,治疗组不良反应发生率为3.61％,两组差异无统计学意义（P＞0.05）.结论：应用地屈孕酮治疗先兆流产的效果显著,其可有效提高患者的血清孕酮值,改善孕妇临床症状,且不良反应轻微,值得在临床上推广使用.

Efficacy of Dydrogesterone in the Treatment of 388 cases threatened abortion

Objective：To analyze the clinical effect of dyprogesterone in the treatment of threatened abortion.Methods：Totally 776 cases of threatened miscarriage pregnant women were divided into two groups,and each group had 388 cases.All the patients had adequate bed rest and nutrition.The patients in the control group were orally given progestin capsules for 7 days with 2 capsules each time and twice a day,while the treatment group was orally given dydrogesterone with the first dose of 40 mg followed by 10 mg every 12 h for 7 days.The clinical sympton alleviation time,serum progesterone,therapeutic efficacy and toxicity before and after the treatment of the two groups were observed.Results：After the treatment,serum progesterone of the treatment group was significantly higher than that of the control group ; the clinical sympton alleviation time of the control group was significantly longer than that of the treatment group（P 〈0.05）,and the pregnancy rate of the control group was 82.98%,while that of the treatment group was 93.81%,and the difference was significant （P 〈 0.05）.The incidence of adverse reactions of the control group was6.19%,that of the treatment group was 3.61%,and the difference was no significant（P 〉0.05）.Conclusion：The progesterone in the treatment of threatened abortion is safe and effective,which can effectively enhance the maternal serum progesterone,improve the clinical symptoms with mild side effects,and it deserves the clinical expansion.