阿托伐他汀对高血压脑出血患者血清神经元特异性烯醇化酶和S100B蛋白水平的影响及疗效观察

目的：探讨阿托伐他汀对高血压脑出血患者血清神经元特异性烯醇化酶（NSE）和S100B蛋白水平的影响及疗效观察.方法：选取高血压脑出血患者84例,随机分为观察组42例和对照组42例.两组患者均予以监控生命体征、控制颅压和血压、止血等常规治疗.观察组患者加用口服阿托伐他汀钙20 mg,qd,连用14d.评定两组患者治疗后的临床疗效及不良反应,并比较两组治疗前后血清NSE和S100B蛋白水平的变化.结果：治疗14 d后,两组患者血清NSE和S100B蛋白水平均有明显下降（P＜0.05或0.01）,且观察组下降幅度较对照组更明显（P＜0.05）;同时观察组患者的临床总有效率为92.86％,明显高于对照组的76.19％（P＜0.05）,两组患者治疗中均未发生明显药品不良反应.结论：阿托伐他汀治疗高血压脑出血的具有肯定的疗效,安全性较优,作用可能与其降低血清NSE和S100B水平,保护大脑神经元细胞密切相关.

Influence and Curative Effect Observation of Atorvastatin on Serum Neuron Specific Enolase (NSE) and S100B Protein Levels in Patients with Hypertensive Cerebral Hemorrhage

Objective：To discuss the influence and curative effect of atorvastatin on serum neuron-specific enolase （NSE） and S100B protein levels in the patients with hypertensive cerebral hemorrhage.Methods：Totally 84 patients with hypertensive cerebral hemorrhage were selected and randomly divided into the observation group and the control group with 42 cases in each.The patients in the two groups were both given the routine medical treatment,such as monitoring vital signs （VS）,controlling intracranial and blood pressure,hemostasis and so on.The patients in the observation group were additionally given 20mg atorvastatin calcium orally once a day for 14 days.The clinical curative effect and untoward effect of the patients in the two groups after the medical treatment were evaluated,and the changes in serum NSE and S100B protein levels before and after the medical treatment were compared.Results：After the 14-day medical treatment,serum NSE and S100B protein levels of the patients in the two groups were obviously declined（P 〈 0.05or P 〈0.01）,and the declining rate in the observation group was much higher than that in the control group （P 〈0.05）.Meanwhile,the total clinical efficiency in the observation group was 92.86%,which was much higher than that in the control group （76.19%） （P 〈 0.05）.No obvious drug adverse reaction in the two groups appeared.Conclusion：Atorvastatin shows reliable curative effect in the patients with hypertensive cerebral hemorrhage with favorable safety,and the underlying mechanism has close relationship with the ability of reducing serum NSE and S100B levels and protecting brain neuronal cells.