滋肾骨康丸对去卵巢大鼠骨质疏松症作用的实验研究

目的：探讨滋肾骨康丸对去卵巢大鼠骨质疏松症的治疗作用。方法：选择雌性大鼠50只，随机分为空白组、模型组、高剂量组、低剂量组和尼尔雌醇组5组，每组10只，造模后两周开始灌胃给药，治疗组按照大（12g/kg）、小（6g/kg）给以滋肾骨康丸，阳性对照组给以尼尔雌醇1．0g/kg，空白组与模型组给以生理盐水，共12周。试验结束后，取样本测骨密度、骨矿含量和血清E2含量的变化。结果：与空白组比，模型组测骨密度、骨矿含量和血清E2含量均明显降低（P〈0．01）；与模型组比，高剂量组、低剂量组和尼尔雌醇组均可使骨密度、骨矿含量和血清E2含量升高（P〈0．01）。结论：结果表明，滋肾骨康丸具有较好的治疗骨质疏松症的作用，值得进一步的开发和利用。

Experimental Study of Zishengukang Pill on Osteoporosis Rats of Ovaries-removed

Objective： To investigation the effects of Zishengukang Pill on osteoporosis rats of ovaries-removed. Methods： 50 rats were divided into control group, model group, high group, low group and nilestriol group randomly, 10 rats in each group. NS were given to control group and model group, Zishengukang Pill 12 g/kg, 6 g/kg to high group and low group, and nilestriol to nilestriol group. After 12 weeks, bone density, the contents of bone-ore and E2 in serum were examined. Results： Bone density, the contents of bone-ore and E2 were decreased in model group than that of control group（P 〈 0.01 ）. Bone density, the contents of bone-ore and E2 were increased in high group, low group and nilestfiol group than that of model group（P 〈 0. 01）. Conclusion： there were good effects of Zishengukang Pill on osteoporosis rats of ovaries-removed. It is worth popularizing.