脑塞通的脑保护作用研究

目的 :观察脑塞通对动物脑血流量、脑栓塞以及血液流变学的影响。方法 :用家兔和大脑中动脉 (A)栓塞模型及双侧颈总A结扎大鼠以及角叉菜胶诱导大鼠血栓模型 ,预防或治疗给药 7d ,观察脑塞通对这些模型的影响。结果 :脑塞通 1.0 ,2 .0 ,4.0g·kg^-13个剂量均能显著增加麻醉家兔的脑血流量 ;明显减少大脑中A栓塞模型大鼠脑梗死范围 ;降低脑缺血再灌大鼠的体征指数 ,并可明显降低脑含水量 ,提高脑组织中抗氧化酶GPx ,CAT的活力 ;降低LPO和LD含量 ;能明显缩短角叉菜胶诱导血栓模型大鼠体内血栓长度 ,并能改善血液流变学 ;明显延长小鼠耐缺氧时间。结论 :脑塞通能增加家兔脑血流 ,改善缺血再灌大鼠的脑水肿、脑组织损伤以及神经体征 ,减少局灶性脑血栓引起的脑梗死范围 ,延缓体内血栓形成 ,并具有抗缺氧的作用 ,对实验性脑梗死有明显的保护作用。

Study of Cerebral Protective Effects of Naosaitong in Animals

Objective: To investigate the influence of N aosaitong (NST) on the cerebral blood flow (CBF), the infarct areas and blood rh eology in animals. Method: NST's cerebral protective effec ts were investigated by using middle cerebral artery occlusion(MCAO), bilateral common carotid artery ligation, and carrogeenin-induced thrombus model rats, be ing administrated with medicine for seven days. Result: Th ree dosage groups of NST increased CBF in anesthetized rabbits, reduced the inf arct areas in MCAO rats, decreased the physical sign indexes, and water quantiti es. They inceased the activities of Glutathione peroxidase(GPX) and Catalase ( CAT), decreased the contractions of Lipid peroxidase (LPO) and Lactate(LD) in th e cerebral ischemia-reperfusion rats; shortened the longth of thrombus and impr oved the blood rheology in the carrogeenin-induced thrombus model rats, and pro longed hypoxia-resisting time in mice. Conclusion: NST ca n evidently increase CBF in rabbits, improve the cerebral edema brain tissues'i njure and nervous physical sign indexes in the cerebral ischemia-reperfusion ra ts, reduce the infarct areas in MCAO rats, postpone thrombosis course and have a ntioxidation effects, which show that NST can obviously protect the brain tissue s in the experimental cerebral infarct model rats.