| 氟西汀抑制野百合碱诱导的大鼠右心室肥厚及GATA结合蛋白4的表达 |
| |
| 引用本文： | 王寒明,高杰,章新华,王怀良.氟西汀抑制野百合碱诱导的大鼠右心室肥厚及GATA结合蛋白4的表达[J].解剖科学进展,2010,16(1):58-61. |
| |
| 作者姓名： | 王寒明 高杰 章新华 王怀良 |
| |
| 作者单位： | 1. 中国医科大学药学院临床药理教研室,辽宁沈阳,110001
2. 中国医科大学基础医学院解剖教研室,辽宁沈阳,110001 |
| |
| 基金项目： | 国家自然科学基金(No.30271510,No.30572194);;辽宁省教育厅高等学校科学研究项目(No.06L516) |
| |
| 摘 要： | 目的研究氟西汀(Fluoxetine,Flu)抑制野百合碱(Monocrotaline,MCT)诱导的大鼠右心室肥厚与(GATA binding protein 4)结合蛋白4(GATA-4)表达的关系。方法建立MCT诱导的慢性肺动脉高压大鼠模型。灌胃给予大鼠不同剂量的Flu,检测右心室肥厚指标和心室GATA-4蛋白表达水平。结果MCT诱导的大鼠右心指数及右心室GATA-4蛋白表达均比正常对照组显著增加,Flu剂量依赖地抑制了右心指数及右心室GATA-4表达增加,而各组间左心室和室间隔的GATA-4表达没有明显变化。结论选择性5-羟色胺再摄取抑制剂Flu抑制MCT诱导的大鼠右心室肥厚可能与抑制GATA-4表达有关。
|
| 关 键 词： | 野百合碱 氟西汀 结合蛋白4 5-羟色胺 右心室肥厚 大鼠 |
Involvement of GATA-4 in fluoxetine-produced inhibition on right ventricular hypertrophy by monocrotaline in rats |
| |
| WANG Han-ming,GAO Jie ,ZHANG Xin-hua ,WANG Huai-liang.Involvement of GATA-4 in fluoxetine-produced inhibition on right ventricular hypertrophy by monocrotaline in rats[J].Progress of Anatomical Sciences,2010,16(1):58-61. |
| |
| Authors: | WANG Han-ming GAO Jie ZHANG Xin-hua WANG Huai-liang |
| |
| Institution: | 1.Department of Clinical Pharmacology;2.Department of Anatomy;China Medical University;Shenyang 110001 China |
| |
| Abstract: | Objective To study the involvement of GATA bing protein 4(GATA-4) in fluoxetine-produced inhibition on right ventricular hypertrophy induced by monocrotaline(MCT) in rats.Methods MCT-induced pulmonary arterial hypertension in rats was established.Rats were treated with different doses of fluoxetine by gavages.The variables of right ventricular hypertrophy and GATA-4 expression in ventricle were measured.Results MCT caused right ventricular hypertrophy and increased expression of GATA-4 in the right,rather t... |
| |
| Keywords: | monocrotaline fluoxetine GATA binding protein 4 5-HT right ventricular hypertrophy rat |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
