Regulatory T cells and tumour immunity - observations in mice and men |
| |
| Authors: | Gallimore Awen Godkin Andrew |
| |
| Affiliation: | Medical Biochemistry and Immunology, Henry Wellcome Building, Heath Park, Cardiff University, Cardiff, CF14 4XN, UK. gallimoream@cf.ac.uk |
| |
| Abstract: | An enormous body of work supports a role for CD4+ CD25+ regulatory cells (Tregs) in shaping the immune response to tumours. Indeed, there is evidence that the cells impede effective tumour immunosurveillance, inhibit vaccine-induced antitumour immune responses and promote tumour progression. Studies exploring the impact of Tregs on tumour development are discussed in the context of manipulating this T-cell population for the purpose of cancer immunotherapy. |
| |
| Keywords: | cancer regulation immune surveillance |
| 本文献已被 PubMed 等数据库收录！ |
|
