脑神经生长素治疗急性脑出血所致神经功能障碍

目的：比较脑神经生长素（ＣＮＧ）与胞磷胆碱（Ｃｉｔ）治疗急性脑出血所致神经功能障碍的疗效。方法：ＣＮＧ组５６例［男性３２例，女性２４例；年龄（６１±ｓ５）ａ］，病程（３．８±１．５）ｄ；出血量（２０．５±２．３）ｍＬ；用ＣＮＧ２～４ｍＬ，ｉｍ，ｑｄ，用药１０～２０ｄ者３０例，２１～３０ｄ者２６例。Ｃｉｔ组６０例［男性３８例，女性２２例；年龄（５９±９）ａ］，病程（３．５±１．７）ｄ；出血量（１９．３±２．８）ｍＬ；Ｃｉｔ５００ｍｇ于５％葡萄糖注射液５００ｍＬ中静脉滴注，ｑｄ，用药１０～２０ｄ者２４例，２１～３０ｄ者３６例。结果：ＣＮＧ组与Ｃｉｔ组显效率分别为７３％和５４％（Ｐ＜０．０５），未见明显不良反应。结论：ＣＮＧ是治疗急性期脑出血所致神经功能障碍安全有效的新药

Cranial nerve growthine in treating neurologic disorders caused by acute cerebral hemorrhage

AIM: To compare the therapeutic effects between cranial nerve growthine (CNG) and citicoline (Cit) in the treatment of the disturbance of nervous function caused by acute cerebral hemorrhage. METHODS: CNG group 56 patients M 32, F 24; age (61±s 5) a; course of disease (3.8±1.5) d; hemorrhage volume (20.5±2.3) mL] were treated with CNG injection, 2_4 mL, im, qd, 30 patients for 10_20 d, 26 patients for 21_30 d. Cit group 60 patients M 38, F 22; age (59±9) a; course of dis_ ease (3.5±1.7) d; hemorrhage volume (19.3± 2.8) mL] were injected Cit 500 mg added to 5% glucose 500 mL, iv drip, qd, 24 patients for 10_20 d, 36 patients for 21_30 d. RESULTS: The excellent response rate was 73% in CNG group, while 54% in Cit group (P<0.05). There were no obvious adverse reactions. CONCLUSION: CNG is safe and effective for the treatment of neurologic disorders caused by acute cerebral hemorrhage.