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乙哌立松治疗紧张型头痛75例
引用本文:贺斌,邵福源.乙哌立松治疗紧张型头痛75例[J].中国新药与临床杂志,1999,18(6):354-356.
作者姓名:贺斌  邵福源
作者单位:中国人民解放军第二军医大学附属长征医院神经内科,上海,200003
摘    要:目的:验证乙哌立松对伴有颅周肌肉收缩的急性或慢性紧张型头痛的临床疗效。方法:按国际头痛学会诊断标准,符合要求病人75 例,其中急性紧张型头痛组21 例,慢性紧张型头痛组54 例。以多中心开放研究,给予乙哌立松50 mg , po,tid ×4wk ,观察头痛严重程度、颈肩部肌肉压痛阈值和压痛总评分等,记录服药前, 服药wk 1 ,2 ,4 末指标的变化。结果:乙哌立松对伴有颅周肌肉收缩的紧张型头痛总有效率为91 % 。治疗1wk 53 例病人肌肉压痛阈值和( 或) 压痛总评分与治疗前相比差别有显著意义( P< 0 .01 和P< 0 .05) ,急性紧张型头痛与慢性紧张型头痛病人同期疗效比较差别有显著意义( P< 0 .05) ;无效7 例;不良反应3 例。结论:乙哌立松治疗紧张型头痛安全有效,对急性紧张型头痛疗效优于慢性紧张型头痛。

关 键 词:头痛  肌收缩  乙哌立松  多中心研究

Eperisone in treating tension-type headache in 75 patients
HE Bin,SHAO Fu-Yuan.Eperisone in treating tension-type headache in 75 patients[J].Chinese Journal of New Drugs and Clinical Remedies,1999,18(6):354-356.
Authors:HE Bin  SHAO Fu-Yuan
Abstract:AIM: To evaluate the clinical effects of eperisone in the treatment of chronic tension_type headache associated with pericranial muscle contraction. METHODS: According to the diagnostic criterion of the International Headache Society, 75 patients with tension_type headache associated with pericranial muscle contraction were composed by episodic form 21 patients and chronic form 54 patients. An open and multicenter clinical study was adopted. The patients were administrated epirisone 50 mg, tid at the onset of the headache attack for 4 wk. Multiple subjective and objective parameters were carefully observed including the location of headache, the duration of the symptoms, the frequency of the attack, the degree of severity, the degree of stiffness in the nucha region and shoulders,pressure pain threshold and total tenderness scoring.The changes of each parameters were recorded at the end of wk 1, 2, 4 after administration. RESULTS: The total rate of patients showing effectiveness was 91%.The pressure pain threshold and/or the total tenderness scoring in 53 patients improved significantly after the drug therapy for 1 wk(P<0.05). The same result was also seen in the episodic tension_type headache compared to the chronic one(P<0.05). Seven patients showed no response to the drug.Adverse reactions were seen in 3 patients. CONCLUSION: Eperisone was a safe and effective drug in treating patients with tension-type headache associated with pericranial muscle contraction. It proved more effective in episodic form than in chronic one.
Keywords:headache  muscle contraction  eperisone  multicenter studies
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