成本-效果分析应用于3种根除幽门螺杆菌的治疗方案

目的 :探讨不同药物临床治疗方案对相同疾病的经济效果。方法 :根据文献选择 14 1例HP阳性病人 ,给予 3种不同的治疗方案 (A组 :奥美拉唑+克拉霉素 +阿莫西林 ,疗程 1wk ;B组药物同A组 ,治疗时间延长 1倍 ;C组 :胶体铋剂 +阿莫西林+甲硝唑 ,疗程同B组 )。运用药物经济学的成本_效果分析方法进行评价。结果 :A ,B ,C 3种方案的总成本分别为 14 85 .2 ,2 40 8.8,976.4元 ;其效果分别为 89.6% ,95 .7% ,71.7%。结论 :A方案为最佳治疗方案

Cost-effectiveness analysis of 3 drug regimens in eradicating Helicobacter pylori

AIM: To evaluate the economic effectiveness in different pharmaco_therapeutic schemes for Helicobacter pylori(HP) infection patients. METHODS: One hundred and forty_one patients with HP infections from literature reports were divided into three groups A, B and C. They received different therapeutic schemes A: omeprazole (20 mg, po bid×7 d)+clarithromycin (500 mg, po bid×7 d)+amoxicillin (1000 mg, po bid×7 d); B: The drugs same as A, the therapeutic course twice A; C: colloidal bismuth subcitrate (240 mg, po bid×14 d)+amoxicillin (1000 mg, po bid×14 d)+metronidazole (400 mg, po bid×14 d)]. RESULTS: The costs of A, B, C regimens were RMB 1485.2, 2408.8 and 976.4 yuans, respectively, and the benefits were 89.6%, 95.7% and 71.7%, respectively. CONCLUSION: According to the evaluation with pharmacoeconomic cost_effectiveness analysis, A is the best scheme.c supplements help to resume sound nutritional states, normal structure and function of testicle after scalds. Methods:A model of 20% TBSA deeper second degree scald was made in rats when the rats had been fed zinc deficient chows for one week. Then the rats were divided into three groups fed chows different in zinc concentrations. Zinc concentrations were 1.6 μg/g, 24 7 μg/g, 286 9 μg/g respectively. A group fed normal zinc content (24 7 μg/g) chows before and after scalds was designed as control. All rats were pair fed to the group fed low zinc content chows. The contents of Zn, Cu, Mg, Ca, DNA, protein and testosterone of testicles were analyzed. Morphological changes were observed too. Results:Zinc content, DNA and testosterone contents were improved markedly, and the structure of convoluted seminiferous tubule got normal after zin had been supplemented. Wwight and protein contents of testicle were improved to some extent too.Conclusion:Zinc supplements, especially high zinc supplements, help to improve the nutritional states of testicle, promote endogenous synthesis of testosterone, resume normal morphological structure Key words:burn; zinc; testicle