甲亢患者糖耐量的改变及胰岛素抵抗的研究

目的：探讨甲状腺功能亢进症（甲亢）患者糖耐量的改变及其发病机制。方法：对本院收治的84例甲状腺功能亢进患者的临床资料进行回顾性分析,甲亢糖耐量减低者52例,为A组。甲亢糖耐量达诊断糖尿病标准者32例,为B组。正常对照组24例,为C组。进行空腹及早餐后2 h血糖、胰岛素测定,计算胰岛素敏感性指标（ISI）、胰岛细胞分泌功能指标（HOMA-IS）及胰岛素抵抗指数（HOMA-IR）并进行比较。结果：IAI、HOMAIR：A、B两组与C组相比明显低下或增高（P〈0.05）。HOMAIS：A组与C组相比差异无统计学意义,B组与C组相比明显低（P〈0.05）。结论：甲状腺激素可影响糖代谢,出现高血糖及高胰岛素血症,存在胰岛素抵抗。

Changes in glucose tolerance in patients with hyperthyroidism and insulin resistance

Objective： To investigate the hyperthyroidism changes in patients with impaired glucose tolerance and pathogenesis.Methods： 84 patients were treated in our hospital hyperthyroidism clinical data were retrospectively analyzed,hyperthyroidism impaired glucose tolerance in 52 patients,the group A.Up to the standard glucose tolerance diagnosis of hy-perthyroidism,32 patients with diabetes,the group B.24 cases of normal control group,the C group.For fasting and 2 h after breakfast,blood glucose,insulin determination,calculated insulin sensitivity index（ISI）,pancreatic islet cell function index（HOMA-IS） and insulin resistance index（HOMA-IR） and compared.Results： IAI,HOMAIR： A,B group and C group significantly lower or higher than（P0.05）.HOMAIS： A group compared with the C group showed no significant difference,B group was lower compared with C（P0.05）.Conclusion： Thyroid hormone can affect glucose metabolism,resulting in high blood sugar and hyperinsulinemia,insulin resistance.