Astrocytic activation in relation to inflammatory markers during clinical exacerbation of relapsing-remitting multiple sclerosis |
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| Authors: | K Rejdak A Petzold T Kocki J Kurzepa P Grieb W A Turski Z Stelmasiak |
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| Institution: | (1) Department of Neurology, Medical University of Lublin, Lublin, Poland;(2) Department of Neuroinflammation, Institute of Neurology, UCL, London, U.K.;(3) Department of Pharmacology, Medical University of Lublin, Lublin, Poland;(4) Medical Research Center, Polish Academy of Sciences, Warsaw, Poland;(5) Department of Toxicology, Institute of Agricultural Medicine, Lublin, Poland |
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| Abstract: | Summary The study aimed to assay the cerebrospinal fluid (CSF) levels of protein S100B, a biomarker of astrocyte activation in relation
to kynurenic acid (KYNA) and nitric oxide (NO) metabolites, nitrate/nitrite (NOx) concentrations in acute relapse multiple
sclerosis (MS) patients. Twenty relapsing-remitting MS (RR-MS) patients and 10 controls were enrolled. RR-MS patients were
assessed on the expanded disability status scale (EDSS) and underwent lumbar puncture. The CSF KYNA, NOx and S100B levels
were significantly higher in RR-MS group compared to controls (p = 0.01, 0.001, 0.04, respectively). There was a significant correlation between CSF S100B and KYNA (p = 0.01) but not NOx (p > 0.05) in RR-MS. CSF KYNA, NOx or S100B concentrations did not correlate with disease characteristics of MS patients.
Our study suggests the activation of the kynurenine pathway leading to the increase of neuroprotective KYNA in the CSF of
MS patients during acute relapse what contrasts with chronic phases of the disease. |
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| Keywords: | : Kynurenic acid nitric oxide S100B cerebrospinal fluid neuroprotection multiple sclerosis |
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