Intravenous lidocaine for fibromyalgia syndrome: an open trial |
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Authors: | Marcelo Derbli Schafranski Tiago Malucelli Fabíola Machado Hélcio Takeshi Flávia Kaiber Carolina Schmidt Fabielle Harth |
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Institution: | (1) Department of Rheumatology, Santa Casa de Misericórdia, Rua Carlos Osternack, 111, 84010-120 Ponta Grossa, PR, Brazil;(2) Department of Internal Medicine, Santa Casa de Misericórdia, Ponta Grossa, PR, Brazil |
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Abstract: | Fibromyalgia is a disorder characterized by chronic widespread pain. In this study, we investigated the effect of intravenous
infusions of lidocaine in pain and quality of life of patients with fibromyalgia. Twenty-three consecutive patients were included
in the study, which consisted on five sequential intravenous 2% lidocaine infusions with rising dosages (2–5 mg/kg, days 1–5).
Fibromyalgia Impact Questionnaire (FIQ), Health Assessment Questionnaire, and a visual analog scale (VAS) for pain were applied
before the first lidocaine infusion, immediately after the fifth infusion and 30 days after the fifth infusion. A significant
improvement was observed in the FIQ scores after the fifth infusion (73.52 ± 16.56 vs 63.29 ± 21.21, p = 0.02), which was maintained after 30 days (73.52 ± 16.56 vs 63.85 ± 24.59, p = 0.04). Similar results were seen concerning the VAS: 8.19 ± 1.76 vs 6.84 ± 2.44, p = 0.01 and 8.19 ± 1.76 vs 7.17 ± 2.35, p = 0.05, respectively. Intravenous lidocaine infusions are safe and effective in the management of fibromyalgia. |
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Keywords: | Chronic pain Fibromyalgia Lidocaine Sodium channels |
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