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HLA-DRB1/DQB1 susceptibility for autoimmune polyglandular syndrome type II and III in south of Tunisia
Authors:Fourati H  Mahfoudh N  Abida O  Kammoun A  Mnif F  Haddouk S  Ben Ayed M  Ben Hadj Hmida Y  Rekik N  Abid M  Makni H  Masmoudi H
Affiliation:aImmunology Department, Habib Bourguiba Hospital, University of Sfax, 3029 Sfax, Tunisia;bImmunology Department, Hedi Chaker Hospital, University of Sfax, 3029 Sfax, Tunisia;cEndocrinology Department, Hedi Chaker Hospital, University of Sfax, 3029 Sfax, Tunisia
Abstract:

Objectives

The aim of our study was to investigate the association of HLA-DRB1 and HLA-DQB1 alleles with autoimmune polyglandular syndromes (APS) type II and III in a southern Tunisian population.

Patients and methods

Sixty-two unrelated patients with APSII (n = 20) and APSIII (n = 42) and 146 healthy controls were genotyped for HLA class II alleles (DRB1*, DQB1*) by PCR-SSP technique.

Results

An increased frequencies of HLA-DQB1*03:02 (P = 0,02; OR = 2.98) in APSII patients, HLA-DRB1*03 (P = 3 10−6; OR = 4.28) and HLA-DQB1*02:01 (P = 0.04; OR = 1.95) in APSIII patients were found compared to healthy controls. Study of the HLA-DRB1*;DQB1* haplotype frequencies showed a higher occurrence of DRB1*04;DQB1*03:02 and DRB1*03;DQB1*02:01 in APSII patients (P = 4 10−3; OR = 3.31 and P = 0.03; OR = 2.74 respectively) whereas APSIII was only associated with DRB1*03;DQB1*02:01 (P = 7.2 10−8, OR = 4.71).

Conclusion

Our data suggest that the variation in class II HLA alleles and haplotypes could be a genetic factor involved in the susceptibility of APS syndrome.
Keywords:Mots clé  s: Maladie d&rsquo  Addison   Polyendocrinopathies auto-immunes   Antigè  nes des leucocytes humains   Diabè  te de type 1   Thyroï  dite auto-immune
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