Prooxidant-anti-oxidant balance is not associated with extent of coronary artery disease |
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| Authors: | Rahsepar Amir Ali Pourghadamyari Hossein Moohebati Mohsen Parizadeh Seyyed Mohammad Reza Tavallaie Shima Paydar Roghayeh Falsoleiman Homa Dehghani Mashalla Fazlinezhad Afsoon Amini Maral Khorashadizadeh Fatemeh Ghayour-Mobarhan Majid Ferns Gordon A |
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| Affiliation: | aCardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science (MUMS), Mashhad, Iran;bBiochemistry and Nutrition Research Center, Faculty of Medicine, MUMS, Post Code: 9138813944, Mashhad, Iran;cDepartment of Cardiology, Faculty of Medicine, MUMS, Mashhad, Iran;dDepartment of Statistics, Faculty of Medicine, MUMS, Post Code: 9138813944, Mashhad, Iran;eInstitute for Science and Technology in Medicine, Faculty of Health, University of Keele, Staffordshire, United Kingdom |
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| Abstract: | ObjectiveWe have measured the pro-oxidant–antioxidant-balance (PAB) levels in patients with defined coronary artery disease (CAD) and compared them with concentrations in healthy subjects.Design and methodsBased on angiography results, 400 patients with stable CAD were divided into CAD− and CAD+, this being further subcategorized into groups with single-, double- and triple-vessel disease (VD).ResultsThe mean PAB values in the healthy subjects, was significantly lower than for other groups (P < 0.001). In CAD− patients, PAB levels were 123.2 ± 43.9, which was not statistically different compared to groups with SVD, 2VD and 3VD (P > 0.05). In the CAD+ group, PAB values in 1VD, 2VD and 3VD were not significantly different among patients with SVD, 2VD and 3VD (P > 0.05).ConclusionsIn conclusion, we found higher levels of oxidative stress in CAD+ patients compared to healthy subjects. The oxidation level was not related to measures of the extent of CAD such as number of stenosed vessels. |
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| Keywords: | Oxidative stress Coronary artery disease Angiography |
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