| 毛细管电泳法测定富马酸比索洛尔片中主药的含量 |
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| 引用本文： | 张红岭,张慧勤,张振中.毛细管电泳法测定富马酸比索洛尔片中主药的含量[J].中国药房,2007,18(31):2448-2449. |
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| 作者姓名： | 张红岭 张慧勤 张振中 |
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| 作者单位： | 1. 郑州大学药学院,郑州市,450052;河南省分子医学重点学科开放实验室,郑州市,450052
2. 中原工学院材料与化工学院,郑州市,450007 |
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| 摘 要： | 目的:建立以毛细管电泳法测定富马酸比索洛尔片中主药含量的方法。方法:采用熔融石英毛细管柱,运行缓冲液为50mmol·L-1三羟甲基氨基甲烷-磷酸盐缓冲液(pH3.85) ,电压进样为10kV×5s ,工作电压为20kV,柱温为25℃,检测波长为273nm。结果:富马酸比索洛尔检测浓度的线性范围为0.025～0.250mg·mL-1(r=0.999 4) ;平均加样回收率为98.96%(RSD=0.84%)。结论:本方法简便、准确、快速、重现性好,可用于该制剂的质量控制。
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| 关 键 词： | 富马酸比索洛尔 片剂 毛细管电泳法 含量测定 |
| 文章编号： | 1001-0408（2007）31-2448-02 |
| 收稿时间： | 2006-11-22 |
| 修稿时间： | 2007-01-17 |
Content Determination of Bisoprolol Fumarate in Concor by Capillary Electrophoresis |
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| ZHANG Hongling,ZHANG Huiqin,ZHANG Zhenzhong.Content Determination of Bisoprolol Fumarate in Concor by Capillary Electrophoresis[J].China Pharmacy,2007,18(31):2448-2449. |
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| Authors: | ZHANG Hongling ZHANG Huiqin ZHANG Zhenzhong |
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| Abstract: | OBJECTIVE: To determine the content of bisoprolol fumarate in concor by capillary electrophoresis(CE). METHODS: The determination was performed on the following conditions: fused-silica capillary; running buffer: 50 mmol·L-1 trisphosphate buffer(pH 3.85); sample injection method(10kV×5s); running voltage: 20kV; column temperature: 25℃; detect wavelength: 273nm. RESULTS: The linear concentration range of bisoprolol fumarate was from 0.025 to 0.250mg·mL-1(r=0.999 4). The average recovery was 98.96%(RSD=0.84%). CONCLUSION: The method is simple, accurate, rapid and reproducible, and suitable for the quality control of preparation. |
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| Keywords: | Bisoprolol fumarate Tablets Capillary electrophoresis Content determination |
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