| 奥咪拉唑的合成 |
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| 引用本文： | 刘秀兰.奥咪拉唑的合成[J].山西医科大学学报,2002,33(4):330-332. |
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| 作者姓名： | 刘秀兰 |
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| 作者单位： | 山西博康药业有限公司研究室,太原,030021 |
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| 摘 要： | 以对氨基苯甲醚为起始原料，经酰胺化、硝化、还原、成咪唑环制得前体2-巯基-5-甲氧基苯并咪唑。另以3，5-二甲基吡啶为原料经氧化、硝化、甲氧基化、羟甲基化及氯化后制得3，5-二甲基-4-甲氧基-2-氯甲基吡啶。然后在甲醇中缩合、用间氯过氧苯甲酸氧化后制得奥咪拉唑。
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| 关 键 词： | 奥咪拉唑 合成 3 5－二甲基－4－甲氧基－2－氯甲基吡啶 工艺学 |
| 文章编号： | 1007-6611(2002)04-0330-03 |
Synthesis of omeprazole |
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| LIU Xiu,lan.Synthesis of omeprazole[J].Journal of Shanxi Medical University,2002,33(4):330-332. |
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| Authors: | LIU Xiu lan |
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| Abstract: | Omeprazole,a H +,K + ATPase inhibitor,was synthesized from 2 thiol 5 methoxy 1H benzimidazole (2) by condensation with 3,5 dimethyl 4 methoxy 2 chloromethylpyridyne(3) in methyl alcohol and then by oxidation with 3 chloroperoxybenzoic acid.The intermediate 3 was prepared from 3,5 dimethylpyridyne rough oxideation,nitration,methoxiation,hydroxymethylate and chlorination.The intermediate 2 was prepared from p aminoanisole by nitration,reduction and cyclization with carbon disulfide. |
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| Keywords: | Omeprazole 2 thiol 5 methoxy 1H benzimidazole 3 5 dimethylpyridyne technology pharmaceutical |
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