Periodontal manifestations of inflammatory bowel disease: emerging epidemiologic and biologic evidence |
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| Authors: | K. Agossa L. Dubuquoy C. Gower‐Rousseau E. Delcourt‐Debruyne M. Capron |
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| Affiliation: | 1. Univ. Lille, Inserm, CHU Lille, U1008 ‐ Controlled Drug Delivery Systems and Biomaterials, Lille, France;2. Department of Periodontology, School of Dentistry, University of Lille, Lille, FranceBoth authors have contributed equally to the work.;3. Univ. Lille, Inserm, CHU Lille, U995 ‐ LIRIC ‐ Lille Inflammation Research International Center, Lille, France;4. Public Health, Epidemiology and Economic Health, Registre Epimad, Maison Régionale de la Recherche Clinique, Centre Hospitalier Universitaire Régional, Lille Cedex, France;5. Department of Periodontology, School of Dentistry, University of Lille, Lille, France |
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| Abstract: | Inflammatory bowel disease and periodontitis are both described as a disproportionate mucosal inflammatory response to a microbial environment in susceptible patients. Moreover, these two conditions share major environmental and lifestyle‐related risk factors. Despite this intriguing pathogenic parallel, large‐scale studies and basic research have only recently considered periodontal outcomes as relevant data. There are mounting and consistent arguments, from recent epidemiologic studies and animal models, that these two conditions might be related. This article is a comprehensive and critical up‐to‐date review of the current evidence and future prospects in understanding the biologic and epidemiologic relationships between periodontal status and inflammatory bowel disease. |
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| Keywords: | Crohn's disease inflammatory bowel disease periodontal diseases periodontitis |
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