| 慢性精神分裂症病人的免疫功能测定 |
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| 引用本文： | 张向阳,周东丰.慢性精神分裂症病人的免疫功能测定[J].中华精神科杂志,1996,29(4):205-208. |
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| 作者姓名： | 张向阳 周东丰 |
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| 作者单位： | 全北京医科大学精神卫生研究所，北京回龙观医院 |
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| 摘 要： | 为探讨慢性精神分裂症免疫功能状况，对９６例病人Ｔ淋巴细胞亚群、异常淋巴细胞、淋巴细胞转化率和白细胞介素２（ＩＬ－２）分泌细胞进行检测，以２５名健康人为对照。结果显示，病人ＣＤ３阳性细胞、ＣＤ４阳性细胞及ＣＤ４／ＣＤ８、淋巴细胞转化率和体外ＩＬ－２分泌细胞明显降低（Ｐ均＜０．００１），而Ｐ型异常淋巴细胞明显增多（Ｐ＝０．０００１）。提示慢性精神分裂症病人存在免疫功能紊乱，主要表现为免疫功能低下，同时伴有自身免疫倾向。此结果与精神分裂症的病毒感染假说和自身免疫假说相符
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| 关 键 词： | 精神分裂症 免疫测定 T淋巴细胞亚群 白细胞介素2 |
Immuneabnormalitiesinchronicschizophreniapatients |
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| ZhangXiangyang,ZhouDongfeng,ZhangPeiyan,et al..Immuneabnormalitiesinchronicschizophreniapatients[J].Chinese Journal of Psychiatry,1996,29(4):205-208. |
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| Authors: | ZhangXiangyang ZhouDongfeng ZhangPeiyan |
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| Institution: | ZhangXiangyang*,ZhouDongfeng,ZhangPeiyan,etal.*InstituteofMentalHealth,BeijingMedicalUniversity,Beijing100083 |
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| Abstract: | Thepurposeofthisstudywastoexaminetheimmunestatusofthepatientswithchronicschizophrenia.Towardthisend,wemeasuredTcelsubsets,atypicallymphocyte,mitogen-inducedTlymphocyteresponsivenessandmitogen-stimulatedinterleukin-2(IL-2)secretorycelsin96patientsand25healthycontrols.TheresultsshowedthatCD 3andCD 4lymphocytes,theratioofCD4/CD8,mitogen-inducedTlymphocyteresponsiveness,andmitogen-stimulatedIL-2secretorycelsweresignificantlylowerinchronicschizophrenicpatientsthaninnormalcontrols,whereasthenumberofatypicalPlymphocytesintheperipheralbloodweresignificantlyhigherinchronicschizophrenicpatientsthaninnormalcontrols.Weconsideredthatimmunologicabnormalitieswhichindicatedtheloweredcelularimmunefunctionandthepossibilityofautoimmuneprocess,werepresentinchronicschizophrenicpatients;andtheresultofthestudywascompatiblewiththeviraland/orautoimmunehypothesisofschizophrenia. |
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| Keywords: | SchizophreniaImmunoassayT-lymphocytesubsetsInterleukin |
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