二甲双胍联合综合促排卵治疗多囊卵巢综合征的临床研究 |
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引用本文: | 全启花,余琳,陈敦金,杨洁. 二甲双胍联合综合促排卵治疗多囊卵巢综合征的临床研究[J]. 国际医药卫生导报, 2009, 15(10). DOI: 10.3760/cma.j.issn.1007-1245.2009.10.001 |
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作者姓名: | 全启花 余琳 陈敦金 杨洁 |
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作者单位: | 1. 高要市人民医院妇产科,526040 2. 广州医学院第三附属医院妇产科,广州市重症孕产妇救治中心 |
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摘 要: | 目的 探讨二甲双胍联合氯米芬-促性腺激素在多囊卵巢综合征(PCOS)患者治疗中的临床疗效观察.方法 60例PCOS患者,试验组应用二甲双胍联合氯米芬-促性腺激素,对照组只应用CC-hMG/hCG促排卵,具体使用方法同观察组.两组各治疗一个周期.结果 两组治疗情况比较,观察组30例中,2例口服二甲双胍期间妊娠,28例促排卵治疗,有效27例,且均使用hCG诱发排卵,无反应1例;对照组促排卵治疗有效25例,1例因卵巢轻度刺激放弃hCG诱发排卵,无反应5例.有效病例中使用HMG治疗天数及用药剂量观察组分别(3.84±0.6)天和(7.84±1.8)支,对照组分别为(4.84±1.6)天和(9.34±2.7)支.两组比较差异有显著性(P<0.01).结论 二甲双胍联合氯米芬可有效地改善PCOS患者的胰岛素抵抗,降低血雄激素水平,诱导排卵,并恢复生育功能.
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关 键 词: | 二甲双胍 多囊卵巢综合征 氯米芬 |
Clinical research of metformin combined ovulation therapy in women with polycystic ovsry syndrome |
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Abstract: | Objective To investigate the clinical effects of metformin combined ovulation therapy on women with polycystie ovary syndrome(PCOS).Methods sixty-patients with PCOS were classified into 2 groups, the test group were treat by dimethyl biguanide and clomiphene and CC-hMG/hCG, the control group only used CC-hMG/hCG, all of them were be treated one cycle.Results there were 2 case had pregnancy during taking dimethyl biguanide orally. Effective case were 27, that is 27/28, and the time and the dose of use the CC-hMG/ hCG were (3.84±0.6)days and(7.84±1.8) rami individually, only one case were inefficacious.the control group had 25 effective case, and the time and the dose of use the CC-hMG/hCG were (4.84±1.6) days and (9.34±2.7) rami individually, there were significant difference between the two groups(P<0.05).Conclusion Metformin may effectively improve insulin resistance, reduce serum androgen level, and recover ovulation function in women with PCOS. |
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Keywords: | polycystic ovary syndrome metformin clomiphene |
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