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Production of hematopoietic stem cell-chemotactic factor by bone marrow stromal cells
Authors:Cherry,    Yasumizu, R   Toki, J   Asou, H   Nishino, T   Komatsu, Y   Ikehara, S
Abstract:Chemotactic factors produced by stromal cells in the bone marrow are characterized. Two kinds of factors produced by stromal cell lines are identified using blind-well Boyden's Chambers; one is a neutrophil- chemotactic factor and the other a hematopoietic stem cell (HSC)- chemotactic factor. The latter attracts blastic cells in a low-density fraction, which are Thy1lo, wheat germ agglutinin (WGA)hi, H-2Khi, Ly-1- , Ly-2-, L3T4-, Ly5-, and slg-. The molecular weight of this HSC- chemotactic factor is estimated to be more than 200 kD. Putative cytokines and growth factors, such as granulocyte colony-stimulating factor (CSF), macrophage CSF, granulocyte-macrophage CSF, stem cell factor (SCF), interleukin (IL)-6, and IL-3, do not possess HSC- chemotactic activity. These findings strongly suggest that bone marrow stromal cells produce a new factor that attracts HSCs.
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