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| 阿司匹林对大鼠肺缺血-再灌注损伤的影响 | |
| 引用本文： | 冯友权,孟尽海,白洁.阿司匹林对大鼠肺缺血-再灌注损伤的影响[J].宁夏医学杂志,2011,33(5):396-398. |
| 作者姓名： | 冯友权 孟尽海 白洁 |
| 作者单位： | 1. 宁夏自治区第五人民医院,宁夏,石嘴山,753000 2. 宁夏医科大学附属医院,宁夏,银川,750004 3. 宁夏科大学,宁夏,银川,750004 |
| 摘 要： | 目的通过建立大鼠肺缺血再灌注损伤（Ischemia Reperfusion Injury,IR）模型,观察阿司匹林（Ace-tylsalicylic Acid,ASA）对大鼠肺缺血再灌注损伤的影响。方法将35只清洁级雄性SD大鼠随机分为5组,假手术组：术中仅气管插管,开胸,机械通气;缺血再灌注加溶媒组（IR＋溶媒组）：行缺血处理（左肺门夹闭）前30min,腹腔注射无水乙醇1.0ml/kg,左肺门夹闭45min,松开阻断夹再灌注2h;缺血再灌注加阿司匹林低剂量组、中剂量组和高剂量组（ASA 50组、ASA 100组、ASA 200组）：行缺血再灌处理前30min分别给予不同剂量的阿司匹林。各组处理完毕后,心脏采血并处死动物,取左肺组织制作组织匀浆,测定肺组织匀浆中SOD活性、MDA含量、NO活性、NOS活性、MPO活性。结果左肺缺血45min,再灌注2h的IR＋溶媒组大鼠肺组织SOD活性低于假手术组（P〈0.05）,MDA含量高于假手术组（P〈0.05）,NO和NOS活性低于假手术组（P〈0.05）,MPO活性高于假手术组（P〈0.05）,而缺血再灌注加阿司匹林各剂量组SOD活性高于IR＋溶媒组,MDA含量低于IR＋溶媒组,NO和NOS活性高于IR＋溶媒组,MPO活性低于IR＋溶媒组。结论阿司匹林能减轻肺缺血再灌注损伤。 |
| 关 键 词： | 阿司匹林 SD大鼠 肺缺血再灌注损伤 |
The effects of aspirin on pulmonary ischemia-reperfusion injury in rats |
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| FENG You-quan,et al..The effects of aspirin on pulmonary ischemia-reperfusion injury in rats[J].Ningxia Medical Journal,2011,33(5):396-398. | |
| Authors: | FENG You-quan |
| Institution: | FENG You-quan,et al.(the Fifth People's Hospital of Ningxia,Shizuishan 753000,China) |
| Abstract: | Objective To establish a model of pulmonary ischemia-reperfusion injury in rats,and to observe the effects of aspirin on pulmonary ischemia-reperfusion injury in rats.Methods 35 SD rats were randomly divided into 5 groups:sham operation group(open chest,Tracheal intubation and mechanical ventilation were performed simply),ischemia-reperfusion group plus solvent group(30minuts before ischemia,anhydrous alcohol was injected intraperitoneal by 1.0ml/kg) and three aspirin groups(the dose of them were 50,100,200... |
| Keywords: | Aspirin SD rats Lung ischemia-reperfusion injury |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |