| 大鼠心肺复苏即刻应用肝素抗凝对血清MDA、SOD的影响 |
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| 引用本文： | 海克蓉,于芝,马金孝,刘红. 大鼠心肺复苏即刻应用肝素抗凝对血清MDA、SOD的影响[J]. 宁夏医学杂志, 2011, 33(3): 207-208 |
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| 作者姓名： | 海克蓉 于芝 马金孝 刘红 |
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| 作者单位： | 1. 宁夏自治区人民医院,宁夏,银川,750021
2. 宁夏医科大学附属医院,宁夏,银川,750004 |
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| 摘 要： | 目的探讨窒息性心跳停鼠心肺复苏（CPR）开始即刻肝素抗凝对血清丙二醛（MDA）、超氧化物歧化酶（SOD）的影响。方法健康12-16周龄、体重450—500g的SD大鼠30只，随机分为对照组（sham组），常规复苏组（AD组，窒息性心搏停止＋常规心肺复苏），肝素抗凝组（AD＋Hep组，窒息性心搏停止＋复苏开始即刻肝素抗凝＋常规心肺复苏），每组各10只。自主循环恢复（ROSC）后2h处死实验动物，取血清测丙二醛（MDA）含量、超氧化物歧化酶（SOD）活性。结果与常规复苏组相比，肝素抗凝组MDA含量降低（P〈0．01），SOD活性升高（P〈0．05）。结论大鼠心肺复苏开始即刻肝素抗凝能减轻心脏骤停后血中MDA的生成，增加SOD活性，对心肺复苏后再灌注损伤有一定的治疗作用。
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| 关 键 词： | 心肺复苏术 MDA SOD |
Effect of heparin administrated immediately after CPR started in asphyxia cardiac arrest rat on MDA SOD in blood |
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| HAI Ke-rong,YU Zhi,MA Jing-xiao,et al.. Effect of heparin administrated immediately after CPR started in asphyxia cardiac arrest rat on MDA SOD in blood[J]. Ningxia Medical Journal, 2011, 33(3): 207-208 |
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| Authors: | HAI Ke-rong YU Zhi MA Jing-xiao et al. |
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| Affiliation: | HAI Ke-rong,YU Zhi,MA Jing-xiao,et al.(Ningxia People's Hospital,Yinchuan 750021,China) |
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| Abstract: | Objective To explore effect of heparin administrated immediately after CPR started in asphyxia cardiac arrest rat on MDA and SOD in blood.Methods Thirty Sprage Dawley rats were randomly divided into three groups:sham group,AD group(asphyxia cardiac arrest+ CPR) and AD+Hep group(asphyxia cardiac arrest+ CPR+ heparin),10 rats in each group.The animals were killed at 2h after ROSC in AD and AD+Hep group.SOD and MDA in blood were determined by Xanthin onedase technique and thiobarbituric acid technique respecti... |
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| Keywords: | MDA SOD |
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