A complex Polycomb issue: the two faces of EZH2 in cancer |
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Authors: | Hock Hanno |
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Affiliation: | Cancer Center, Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. hock.hanno@mgh.harvard.edu |
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Abstract: | In the April 1, 2012, issue of Genes & Development, Simon and colleagues (pp. 651-656) demonstrated that the disruption of Ezh2 in mice is sufficient to cause T-acute lymphoblastic leukemia (T-ALL). Moreover, in concert with concurrent studies, the authors revealed that similar mechanisms are involved in human T-ALL. These data contrast with previous findings showing that increased EZH2 activity promotes cancer. |
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Keywords: | T-ALL EZH2 PRC2 leukemia JARID2 DNMT3A |
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