Ability of ceftibuten to induce the class-I beta-lactamases of Enterobacter cloacae, Serratia marcescens, and Enterobacter aerogenes

Ceftibuten, like cefotaxime, was observed to be a weak inducer of the class-I beta-lactamases of Enterobacter cloacae, Serratia marcescens, and Enterobacter aerogenes. In contrast, cefoxitin and imipenem induced these enzymes strongly at subinhibitory concentrations.