| 糖链抗原50和242对结直肠癌诊断的价值 |
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| 摘 要： |
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| 关 键 词： | 诊断 糖链抗原50 糖链抗原242 血清肿瘤标记物 结直肠癌 |
Clinical value of carbohydrate antigen 50 and carbohydrate antigen 242 in the diagnosis of colorectal carcinoma] |
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| Authors: | Cong-Wu Huang Lan Bai |
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| Institution: | Institute for Digestive Diseases of PLA, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. |
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| Abstract: | OBJECTIVE: Carbohydrate antigen 50 (CA50) and 242 (CA242), recently recognized as serum tumor markers, are studied for their value in the diagnosis of the colorectal carcinoma. METHODS: This study included 48 patients with benign bowel disease and 71 patients with colorectal carcinoma, whose serum CA50 and CA242 levels were measured by immunoradiometric assay. RESULTS: The total positivity of CA50 and CA242 in colorectal carcinoma cases were 69.0% and 73.2% respectively, and were only 6.3% and 8.3% in benign cases. In non-metastatic colorectal carcinoma cases, the positivity rates for CA50 and CA242 were 52.8% and 44.4% respectively, which were 82.8% and 88.6% in cases with metastasis. Marked elevation in CA242 level was noted in the patients with colon carcinoma (77.5%). But at early stage of the malignancy, both tumor markers had low sensitivity. CONCLUSION: CA50 and CA242 are valuable tumor markers in the diagnosis of colorectal carcinoma. |
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