Photodynamic therapy of nodular basal cell carcinoma with multifiber contact light delivery. |
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Authors: | Marcelo Soto Thompson Stefan Andersson-Engels Sune Svanberg T Johansson Sara Palsson Niels Bendsoe A Derjabo J Kapostins Unne Stenram J Spigulis Katarina Svanberg |
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Institution: | Lund University Medical Laser Centre, Lund, Sweden. |
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Abstract: | To overcome the limited treatment depth of superficial photodynamic therapy we investigate interstitial light delivery. In the present work the treatment light was delivered using a system in which three or six clear-cut fibers were placed in direct contact with the tumor area. This placement was thought to represent a step toward general purpose interstitial PDT. Twelve nodular basal cell carcinomas were treated employing delta-aminolevulinic acid and 635 nm laser irradiation. Fluorescence measurements were performed monitoring the buildup and subsequent bleaching of the produced sensitizer protoporphyrin IX. The treatment efficacy, judged at a 28-month follow-up, showed a 100% complete response. Two punch excisions at 7 months converted two partial responses to complete responses. One patient failed to appear at all follow-up sessions. The outcome of the treatments was comparable to superficial photodynamic therapy in terms of histological, clinical, and cosmetic results. |
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