丹参注射液干预治疗对溃疡性结肠炎高凝状态的影响

目的:观察丹参注射液干预治疗溃疡性结肠炎的临床疗效及对其血液流变学、D-二聚体的影响.方法:对照组50例给予柳氮磺胺吡啶口服,治疗组50例加用丹参注射液静脉滴注.15天为1个疗程,连用2个疗程.治疗前和1个疗程后测定血液流变学指标、血浆D-二聚体水平,疗程结束后作疗效评定.结果:治疗组临床综合疗效优于对照组(P＜0.05).治疗组治疗后血液流变学指标、血浆D-二聚体水平均较治疗前明显下降(P＜0.05或P＜0.01),对照组变化不明显.结论:丹参注射液干预治疗溃疡性结肠炎可改善其血液高凝状态,从而阻断肠黏膜微血栓形成,提高临床疗效.

The Effect on Hypercoagulable State of Ulcerative Colitis Patients by Intervening Treatment of Danshen Injection

Objective:Clinical observation of Danshen injection intervention of cure for ulcerative colitis(UC) and effects on hemorrheology and plasma D dimmer of UC patients.Methods:The control group (n=50) was treated with sulfasalazine,and the treatment group (n=50) was treated with Danshen injection combined with the western medicine therapy described above.Two groups were treated for 30 days.The levels of plasma D dimmer and hemorrheology were detected in both groups before and 15 days after the treatment.The therapeutic effects were observed after cure.Results:The comprehensive therapeutic effect of the treatment group was higher than that of the control group (P<0.05).Meanwhile the levels of plasma D dimmer and hemorrheologic parameters were all improved significantly in the treated group 15 days after the treatment (P<0.05,or P<0.01).Conclusion:The intervening treatment of Danshen injection can improve the melicera blood of UC patients and prevent microthrombosis in intestine mucous membrane .The therapy is able to heighten the curative efficacy significantly.